Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099689616> ?p ?o ?g. }
- W2099689616 abstract "The adaptor protein Nck has been shown to link receptor ligation to actin-based signalling in a diverse range of cellular events, such as changes in cell morphology and motility. It has also been implicated in phagocytosis. However, its molecular role in controlling actin remodelling associated with phagocytic uptake remains to be clarified. We show that Nck, which is recruited to phagocytic cups, is required for FcγR but not CR3 induced phagocytosis. Nck recruitment in response to FcγR ligation is mediated by the phosphorylation of tyrosine 282 and 298 in the ITAM motif in the cytoplasmic tail of the receptor. In the absence of FcγR phosphorylation, there is also no recruitment of N-WASP or Cdc42 to phagocytic cups. Nck promotes FcγR-mediated phagocytosis by recruiting N-WASP to phagocytic cups. Efficient phagocytosis, however, only occurs, if the CRIB domain of N-WASP can also interact with Cdc42. Our observations demonstrate that Nck and Cdc42 collaborate to stimulate N-WASP dependent FcγR-mediated phagocytosis." @default.
- W2099689616 created "2016-06-24" @default.
- W2099689616 creator A5005071379 @default.
- W2099689616 creator A5032535198 @default.
- W2099689616 creator A5051858662 @default.
- W2099689616 creator A5065590261 @default.
- W2099689616 creator A5070448149 @default.
- W2099689616 date "2012-01-01" @default.
- W2099689616 modified "2023-10-11" @default.
- W2099689616 title "Nck and Cdc42 co-operate to recruit N-WASP to promote FcγR-mediated phagocytosis" @default.
- W2099689616 cites W1498435062 @default.
- W2099689616 cites W1507572058 @default.
- W2099689616 cites W1524475817 @default.
- W2099689616 cites W1530340727 @default.
- W2099689616 cites W1538520630 @default.
- W2099689616 cites W1545383294 @default.
- W2099689616 cites W1628423641 @default.
- W2099689616 cites W1895473399 @default.
- W2099689616 cites W1978677736 @default.
- W2099689616 cites W1984473379 @default.
- W2099689616 cites W1990689709 @default.
- W2099689616 cites W2004619403 @default.
- W2099689616 cites W2005856423 @default.
- W2099689616 cites W2020422209 @default.
- W2099689616 cites W2021112201 @default.
- W2099689616 cites W2031183440 @default.
- W2099689616 cites W2044084413 @default.
- W2099689616 cites W2049811440 @default.
- W2099689616 cites W2054172043 @default.
- W2099689616 cites W2056363506 @default.
- W2099689616 cites W2057033229 @default.
- W2099689616 cites W2064406341 @default.
- W2099689616 cites W2075265850 @default.
- W2099689616 cites W2087136318 @default.
- W2099689616 cites W2088618181 @default.
- W2099689616 cites W2092917447 @default.
- W2099689616 cites W2093844155 @default.
- W2099689616 cites W2095393268 @default.
- W2099689616 cites W2109860344 @default.
- W2099689616 cites W2110770741 @default.
- W2099689616 cites W2115993724 @default.
- W2099689616 cites W2125753995 @default.
- W2099689616 cites W2128535856 @default.
- W2099689616 cites W2128688376 @default.
- W2099689616 cites W2139094884 @default.
- W2099689616 cites W2147359514 @default.
- W2099689616 cites W2147897016 @default.
- W2099689616 cites W2152511989 @default.
- W2099689616 cites W2164950092 @default.
- W2099689616 cites W2165448884 @default.
- W2099689616 cites W2425249855 @default.
- W2099689616 cites W45421301 @default.
- W2099689616 doi "https://doi.org/10.1242/jcs.106583" @default.
- W2099689616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22454526" @default.
- W2099689616 hasPublicationYear "2012" @default.
- W2099689616 type Work @default.
- W2099689616 sameAs 2099689616 @default.
- W2099689616 citedByCount "30" @default.
- W2099689616 countsByYear W20996896162013 @default.
- W2099689616 countsByYear W20996896162014 @default.
- W2099689616 countsByYear W20996896162015 @default.
- W2099689616 countsByYear W20996896162016 @default.
- W2099689616 countsByYear W20996896162017 @default.
- W2099689616 countsByYear W20996896162018 @default.
- W2099689616 countsByYear W20996896162019 @default.
- W2099689616 countsByYear W20996896162020 @default.
- W2099689616 countsByYear W20996896162021 @default.
- W2099689616 countsByYear W20996896162022 @default.
- W2099689616 countsByYear W20996896162023 @default.
- W2099689616 crossrefType "journal-article" @default.
- W2099689616 hasAuthorship W2099689616A5005071379 @default.
- W2099689616 hasAuthorship W2099689616A5032535198 @default.
- W2099689616 hasAuthorship W2099689616A5051858662 @default.
- W2099689616 hasAuthorship W2099689616A5065590261 @default.
- W2099689616 hasAuthorship W2099689616A5070448149 @default.
- W2099689616 hasBestOaLocation W20996896161 @default.
- W2099689616 hasConcept C11960822 @default.
- W2099689616 hasConcept C125705527 @default.
- W2099689616 hasConcept C142669718 @default.
- W2099689616 hasConcept C1491633281 @default.
- W2099689616 hasConcept C160448771 @default.
- W2099689616 hasConcept C170493617 @default.
- W2099689616 hasConcept C183786373 @default.
- W2099689616 hasConcept C2777553839 @default.
- W2099689616 hasConcept C2780040266 @default.
- W2099689616 hasConcept C2780939953 @default.
- W2099689616 hasConcept C2993400109 @default.
- W2099689616 hasConcept C55493867 @default.
- W2099689616 hasConcept C58207958 @default.
- W2099689616 hasConcept C62478195 @default.
- W2099689616 hasConcept C86803240 @default.
- W2099689616 hasConcept C95444343 @default.
- W2099689616 hasConceptScore W2099689616C11960822 @default.
- W2099689616 hasConceptScore W2099689616C125705527 @default.
- W2099689616 hasConceptScore W2099689616C142669718 @default.
- W2099689616 hasConceptScore W2099689616C1491633281 @default.
- W2099689616 hasConceptScore W2099689616C160448771 @default.
- W2099689616 hasConceptScore W2099689616C170493617 @default.
- W2099689616 hasConceptScore W2099689616C183786373 @default.
- W2099689616 hasConceptScore W2099689616C2777553839 @default.