Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099689816> ?p ?o ?g. }
- W2099689816 endingPage "550" @default.
- W2099689816 startingPage "542" @default.
- W2099689816 abstract "Nucleotide pyrophosphatase/phosphodiesterase (NPP)-type ectophosphodiesterases are found at the cell surface as type-I or type-II transmembrane proteins, but are also found extracellularly as secreted or shedded enzymes. They hydrolyze pyrophosphate or phosphodiester bonds in a variety of extracellular compounds including nucleotides, (lyso)phospholipids and choline phosphate esters. Despite their structurally related catalytic domain, each enzyme has well-defined substrate specificity. Catalysis by NPPs affects processes as diverse as cell proliferation and motility, angiogenesis, bone mineralization and digestion. In addition, there is emerging evidence for non-catalytic functions of NPPs in cell signaling. NPP-type ectophosphodiesterases are also implicated in the pathophysiology of cancer, insulin resistance and calcification diseases, and they hold great promise as easily accessible therapeutic targets." @default.
- W2099689816 created "2016-06-24" @default.
- W2099689816 creator A5047477416 @default.
- W2099689816 creator A5064312456 @default.
- W2099689816 creator A5076199556 @default.
- W2099689816 date "2005-10-01" @default.
- W2099689816 modified "2023-10-10" @default.
- W2099689816 title "NPP-type ectophosphodiesterases: unity in diversity" @default.
- W2099689816 cites W1502955608 @default.
- W2099689816 cites W1577193899 @default.
- W2099689816 cites W1899123775 @default.
- W2099689816 cites W1911073788 @default.
- W2099689816 cites W1964405976 @default.
- W2099689816 cites W1965619867 @default.
- W2099689816 cites W1965913260 @default.
- W2099689816 cites W1966761578 @default.
- W2099689816 cites W1967256581 @default.
- W2099689816 cites W1969824977 @default.
- W2099689816 cites W1976443161 @default.
- W2099689816 cites W1981399177 @default.
- W2099689816 cites W1989934799 @default.
- W2099689816 cites W1992203600 @default.
- W2099689816 cites W1999963107 @default.
- W2099689816 cites W2009923060 @default.
- W2099689816 cites W2014733123 @default.
- W2099689816 cites W2016752237 @default.
- W2099689816 cites W2017914218 @default.
- W2099689816 cites W2022545583 @default.
- W2099689816 cites W2022576887 @default.
- W2099689816 cites W2026202377 @default.
- W2099689816 cites W2027924835 @default.
- W2099689816 cites W2030940694 @default.
- W2099689816 cites W2032722121 @default.
- W2099689816 cites W2034363051 @default.
- W2099689816 cites W2036300688 @default.
- W2099689816 cites W2039173160 @default.
- W2099689816 cites W2039854741 @default.
- W2099689816 cites W2042270801 @default.
- W2099689816 cites W2045372511 @default.
- W2099689816 cites W2047829280 @default.
- W2099689816 cites W2055548002 @default.
- W2099689816 cites W2058628090 @default.
- W2099689816 cites W2059467362 @default.
- W2099689816 cites W2059965072 @default.
- W2099689816 cites W2060700279 @default.
- W2099689816 cites W2062104741 @default.
- W2099689816 cites W2063329465 @default.
- W2099689816 cites W2075738256 @default.
- W2099689816 cites W2076131352 @default.
- W2099689816 cites W2082424812 @default.
- W2099689816 cites W2086284871 @default.
- W2099689816 cites W2088562619 @default.
- W2099689816 cites W2096081051 @default.
- W2099689816 cites W2099040322 @default.
- W2099689816 cites W2107007984 @default.
- W2099689816 cites W2110866485 @default.
- W2099689816 cites W2110939804 @default.
- W2099689816 cites W2111598714 @default.
- W2099689816 cites W2111792754 @default.
- W2099689816 cites W2112455601 @default.
- W2099689816 cites W2113980565 @default.
- W2099689816 cites W2119185962 @default.
- W2099689816 cites W2120639213 @default.
- W2099689816 cites W2122622982 @default.
- W2099689816 cites W2125028230 @default.
- W2099689816 cites W2125198748 @default.
- W2099689816 cites W2133620371 @default.
- W2099689816 cites W2138649565 @default.
- W2099689816 cites W2139032200 @default.
- W2099689816 cites W2139140152 @default.
- W2099689816 cites W2149489509 @default.
- W2099689816 cites W2151817111 @default.
- W2099689816 cites W2163447687 @default.
- W2099689816 cites W2165730698 @default.
- W2099689816 cites W2166149223 @default.
- W2099689816 cites W2169170480 @default.
- W2099689816 cites W2181464160 @default.
- W2099689816 cites W4211224007 @default.
- W2099689816 doi "https://doi.org/10.1016/j.tibs.2005.08.005" @default.
- W2099689816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16125936" @default.
- W2099689816 hasPublicationYear "2005" @default.
- W2099689816 type Work @default.
- W2099689816 sameAs 2099689816 @default.
- W2099689816 citedByCount "331" @default.
- W2099689816 countsByYear W20996898162012 @default.
- W2099689816 countsByYear W20996898162013 @default.
- W2099689816 countsByYear W20996898162014 @default.
- W2099689816 countsByYear W20996898162015 @default.
- W2099689816 countsByYear W20996898162016 @default.
- W2099689816 countsByYear W20996898162017 @default.
- W2099689816 countsByYear W20996898162018 @default.
- W2099689816 countsByYear W20996898162019 @default.
- W2099689816 countsByYear W20996898162020 @default.
- W2099689816 countsByYear W20996898162021 @default.
- W2099689816 countsByYear W20996898162022 @default.
- W2099689816 countsByYear W20996898162023 @default.
- W2099689816 crossrefType "journal-article" @default.
- W2099689816 hasAuthorship W2099689816A5047477416 @default.