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• W2099690691 abstract "Application of neurotrophic factors (NFs) to the cut stump of motor nerves of neonatal rats confers neuroprotection from trauma-induced neuronal death. To test whether motoneurons are capable of responding to endogenously produced NFs, facial motoneurons were genetically modified in vivo to express several NFs and then tested for their response to peripheral nerve damage. Replication-defective adenoviral vectors [Adv.Rous sarcoma virus (RSV)- nf ] representing three families of NFs were constructed that carried genes for brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), glial cell-derived neurotrophic factor (GDNF), and nerve growth factor. Media from cultured cells transduced with Adv.RSV -nf contained NFs that supported the survival of cultured chick sensory neurons in the same manner as recombinant NF standards. When Adv.RSV -nf or an adenoviral vector containing the β-galactosidase gene (Adv.RSV-β-gal) were injected into the facial muscles of neonatal rats the vectors were retrogradely transported to the facial nucleus where the NFs or β-gal were expressed. A fraction (∼10%) of the neurons were transduced as demonstrated by reverse transcriptase-PCR, histochemistry, and immunocytochemistry. In the case of Adv.RSV-BDNF, Adv.RSV-CNTF, and Adv.RSV-GDNF, a significant portion of the facial nucleus neurons was protected, 16.5, 18.2, and 53.3%, respectively, from death after axotomy, showing that neurons are capable of transporting the Adv.RSV- nf , expressing the recombinant NF genes, and responding to the NFs. In the case of Adv.RSV-GDNF, a greater number of facial nucleus motoneurons survived than were transduced, indicating that neighboring untransduced neurons were protected by the GDNF expressed by the transduced neurons by a paracrine mechanism." @default.
• W2099690691 created "2016-06-24" @default.
• W2099690691 creator A5041470164 @default.
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• W2099690691 date "1997-09-01" @default.
• W2099690691 modified "2023-10-17" @default.
• W2099690691 title "Targeted Transduction of CNS Neurons with Adenoviral Vectors Carrying Neurotrophic Factor Genes Confers Neuroprotection That Exceeds the Transduced Population" @default.
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• W2099690691 doi "https://doi.org/10.1523/jneurosci.17-17-06504.1997" @default.
• W2099690691 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6573127" @default.
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