FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099692224> ?p ?o ?g. }

• W2099692224 endingPage "3212" @default.
• W2099692224 startingPage "3207" @default.
• W2099692224 abstract "The tumor suppressor p53 negatively regulates a number of genes, including the proto-oncogene c-Myc, in addition to activating many other genes. One mechanism of the p53-mediated c-Myc repression may involve transcriptional regulation. However, it is not clear whether microRNAs (miRNAs) play a role in the p53-mediated posttranscriptional regulation of c-Myc. In this study, we show that a putative tumor suppressor, miR-145, is expressed through the phosphoinositide-3 kinase (PI-3K)/Akt and p53 pathways. Importantly, p53 transcriptionally induces the expression of miR-145 by interacting with a potential p53 response element (p53RE) in the miR-145 promoter. We further show that c-Myc is a direct target for miR-145. Although miR-145 silences the expression of c-Myc, anti-miR-145 enhances its expression. This specific silencing of c-Myc by miR-145 accounts at least in part for the miR-145-mediated inhibition of tumor cell growth both in vitro and in vivo. Finally, the blockade of miR-145 by anti-miR-145 is able to reverse the p53-mediated c-Myc repression. Together, these results define the role of miR-145 in the posttranscriptional regulation of c-Myc by p53 and suggest that, as a new member of the p53 regulatory network, miR-145 provides a direct link between p53 and c-Myc in this gene regulatory network." @default.
• W2099692224 created "2016-06-24" @default.
• W2099692224 creator A5006769267 @default.
• W2099692224 creator A5009687745 @default.
• W2099692224 creator A5011117247 @default.
• W2099692224 creator A5039382964 @default.
• W2099692224 creator A5041604554 @default.
• W2099692224 creator A5049724219 @default.
• W2099692224 creator A5061422621 @default.
• W2099692224 creator A5074094335 @default.
• W2099692224 creator A5074668225 @default.
• W2099692224 date "2009-03-03" @default.
• W2099692224 modified "2023-10-11" @default.
• W2099692224 title "p53 represses c-Myc through induction of the tumor suppressor <i>miR-145</i>" @default.
• W2099692224 cites W1786563963 @default.
• W2099692224 cites W1881918025 @default.
• W2099692224 cites W1964742508 @default.
• W2099692224 cites W1965714535 @default.
• W2099692224 cites W1966129042 @default.
• W2099692224 cites W1984948591 @default.
• W2099692224 cites W1993646044 @default.
• W2099692224 cites W1993799748 @default.
• W2099692224 cites W1994017669 @default.
• W2099692224 cites W2002995168 @default.
• W2099692224 cites W2018884388 @default.
• W2099692224 cites W2027217537 @default.
• W2099692224 cites W2030120875 @default.
• W2099692224 cites W2039326914 @default.
• W2099692224 cites W2051663161 @default.
• W2099692224 cites W2052512448 @default.
• W2099692224 cites W2062290101 @default.
• W2099692224 cites W2070805824 @default.
• W2099692224 cites W2077221868 @default.
• W2099692224 cites W2079479637 @default.
• W2099692224 cites W2104146201 @default.
• W2099692224 cites W2111101616 @default.
• W2099692224 cites W2113551318 @default.
• W2099692224 cites W2126311004 @default.
• W2099692224 cites W2135836598 @default.
• W2099692224 cites W2138366746 @default.
• W2099692224 cites W2142505369 @default.
• W2099692224 cites W2161222316 @default.
• W2099692224 cites W2161234257 @default.
• W2099692224 cites W2161762726 @default.
• W2099692224 cites W2171407623 @default.
• W2099692224 cites W4302330151 @default.
• W2099692224 doi "https://doi.org/10.1073/pnas.0808042106" @default.
• W2099692224 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2651330" @default.
• W2099692224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19202062" @default.
• W2099692224 hasPublicationYear "2009" @default.
• W2099692224 type Work @default.
• W2099692224 sameAs 2099692224 @default.
• W2099692224 citedByCount "773" @default.
• W2099692224 countsByYear W20996922242012 @default.
• W2099692224 countsByYear W20996922242013 @default.
• W2099692224 countsByYear W20996922242014 @default.
• W2099692224 countsByYear W20996922242015 @default.
• W2099692224 countsByYear W20996922242016 @default.
• W2099692224 countsByYear W20996922242017 @default.
• W2099692224 countsByYear W20996922242018 @default.
• W2099692224 countsByYear W20996922242019 @default.
• W2099692224 countsByYear W20996922242020 @default.
• W2099692224 countsByYear W20996922242021 @default.
• W2099692224 countsByYear W20996922242022 @default.
• W2099692224 countsByYear W20996922242023 @default.
• W2099692224 crossrefType "journal-article" @default.
• W2099692224 hasAuthorship W2099692224A5006769267 @default.
• W2099692224 hasAuthorship W2099692224A5009687745 @default.
• W2099692224 hasAuthorship W2099692224A5011117247 @default.
• W2099692224 hasAuthorship W2099692224A5039382964 @default.
• W2099692224 hasAuthorship W2099692224A5041604554 @default.
• W2099692224 hasAuthorship W2099692224A5049724219 @default.
• W2099692224 hasAuthorship W2099692224A5061422621 @default.
• W2099692224 hasAuthorship W2099692224A5074094335 @default.
• W2099692224 hasAuthorship W2099692224A5074668225 @default.
• W2099692224 hasBestOaLocation W20996922242 @default.
• W2099692224 hasConcept C104317684 @default.
• W2099692224 hasConcept C119056186 @default.
• W2099692224 hasConcept C145059251 @default.
• W2099692224 hasConcept C150194340 @default.
• W2099692224 hasConcept C165864922 @default.
• W2099692224 hasConcept C179185449 @default.
• W2099692224 hasConcept C186310378 @default.
• W2099692224 hasConcept C2778264664 @default.
• W2099692224 hasConcept C2781018059 @default.
• W2099692224 hasConcept C29537977 @default.
• W2099692224 hasConcept C502942594 @default.
• W2099692224 hasConcept C54355233 @default.
• W2099692224 hasConcept C555283112 @default.
• W2099692224 hasConcept C86803240 @default.
• W2099692224 hasConcept C95444343 @default.
• W2099692224 hasConceptScore W2099692224C104317684 @default.
• W2099692224 hasConceptScore W2099692224C119056186 @default.
• W2099692224 hasConceptScore W2099692224C145059251 @default.
• W2099692224 hasConceptScore W2099692224C150194340 @default.
• W2099692224 hasConceptScore W2099692224C165864922 @default.
• W2099692224 hasConceptScore W2099692224C179185449 @default.
• W2099692224 hasConceptScore W2099692224C186310378 @default.

• next