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- W2099694416 abstract "Materials and Methods: The data were obtained from male Wistar rat, weighing 220 to 260 g. Animals were allocated to five groups: Control, Verapamil, AM251, acute Verapamil + AM251, and chronic (injection for 8 days) Verapamil + AM251 groups. The percentage of entries into the open arms of the EPM, the time spent in the open arms, and the number of entries into the closed arms during ten minutes was recorded. Results: Intraperitoneally (IP) injection of AM251 before EPM trial decreased open arms exploration and open arm entry. On the other hand, Verapamil increased open arms exploration and open arm entry. Combined injection of Verapamil and AM251 had conflicting effects on the responses of each of these two compounds alone. AM251 and Verapamil had no effects on the number of closed arm entries. Conclusions: IP injection of CB1 receptor antagonist might have an anxiogenic profile in rat, whereas calcium channel blocker attenuated the anxiogenic effect of AM251. Our results suggest that there is an interaction between functions of L-type Ca 2+ channels and cannabinoid system in anxiety." @default.
- W2099694416 created "2016-06-24" @default.
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- W2099694416 date "2014-11-25" @default.
- W2099694416 modified "2023-09-27" @default.
- W2099694416 title "Interaction Between L-Type Calcium Channels and Antagonist of Cannabinoid System on Anxiety in Male Rat" @default.
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- W2099694416 doi "https://doi.org/10.17795/ajnpp-24450" @default.
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