FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099694536> ?p ?o ?g. }

• W2099694536 endingPage "307" @default.
• W2099694536 startingPage "299" @default.
• W2099694536 abstract "In previous studies, we have mapped quantitative trait loci (QTLs) for hypnotic sensitivity to ethanol using a small recombinant inbred (RI) panel and a large F₂ backcross. Alcohol sensitivity is a major predictor of long-term risk for alcoholism. We remapped hypnotic sensitivity using a new set of 75 RI strains, the LXS, derived from Inbred Long Sleep and Inbred Short Sleep strains. We expected to improve mapping resolution in the QTL regions and to identify novel QTLs for loss of the righting reflex due to ethanol. We used three common mapping algorithms (R/qtl, QTL Cartographer, and WebQTL) to map QTLs in the LXS, and we compared the results. Most mapping studies use only a single algorithm, an approach that may result in failure to identify minor QTLs. We confirmed most of our previously reported QTLs, although one major QTL from earlier work (<i>Lore2</i>) failed to replicate, possibly because it represented multiple linked genes separated by recombination in the RI strains. We also report narrowed confidence intervals, based on mapping with a new genetic resource of more than 4000 polymorphic single-nucleotide polymorphism markers. These narrowed confidence intervals will facilitate candidate gene identification and assessment of overlap with human regions specifying risk for alcoholism. Finally, we present an approach for using these RI strains to assess evidence for candidate genes in the narrowed intervals, and we apply this method to a strong candidate, the serotonin transporter." @default.
• W2099694536 created "2016-06-24" @default.
• W2099694536 creator A5011259402 @default.
• W2099694536 creator A5048615839 @default.
• W2099694536 creator A5057519121 @default.
• W2099694536 creator A5058902481 @default.
• W2099694536 date "2006-06-27" @default.
• W2099694536 modified "2023-10-16" @default.
• W2099694536 title "Confirmation and Fine Mapping of Ethanol Sensitivity Quantitative Trait Loci, and Candidate Gene Testing in the LXS Recombinant Inbred Mice" @default.
• W2099694536 cites W1835754911 @default.
• W2099694536 cites W1860129028 @default.
• W2099694536 cites W1895254745 @default.
• W2099694536 cites W1968269934 @default.
• W2099694536 cites W1983111430 @default.
• W2099694536 cites W1986937650 @default.
• W2099694536 cites W2010972472 @default.
• W2099694536 cites W2012555257 @default.
• W2099694536 cites W2012975927 @default.
• W2099694536 cites W2017774787 @default.
• W2099694536 cites W2019101826 @default.
• W2099694536 cites W2033296058 @default.
• W2099694536 cites W2038980921 @default.
• W2099694536 cites W2045679150 @default.
• W2099694536 cites W2046274864 @default.
• W2099694536 cites W2051337405 @default.
• W2099694536 cites W2056432526 @default.
• W2099694536 cites W2062239829 @default.
• W2099694536 cites W2064451465 @default.
• W2099694536 cites W2071065596 @default.
• W2099694536 cites W2075654334 @default.
• W2099694536 cites W2076357799 @default.
• W2099694536 cites W2076639163 @default.
• W2099694536 cites W2082959056 @default.
• W2099694536 cites W2085229561 @default.
• W2099694536 cites W2108334325 @default.
• W2099694536 cites W2116053845 @default.
• W2099694536 cites W2122233311 @default.
• W2099694536 cites W2155286781 @default.
• W2099694536 cites W2161339778 @default.
• W2099694536 cites W2162196924 @default.
• W2099694536 cites W2164967571 @default.
• W2099694536 cites W2171195450 @default.
• W2099694536 cites W4229601525 @default.
• W2099694536 cites W4229749460 @default.
• W2099694536 cites W4293247451 @default.
• W2099694536 doi "https://doi.org/10.1124/jpet.106.103572" @default.
• W2099694536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16803863" @default.
• W2099694536 hasPublicationYear "2006" @default.
• W2099694536 type Work @default.
• W2099694536 sameAs 2099694536 @default.
• W2099694536 citedByCount "33" @default.
• W2099694536 countsByYear W20996945362012 @default.
• W2099694536 countsByYear W20996945362013 @default.
• W2099694536 countsByYear W20996945362014 @default.
• W2099694536 countsByYear W20996945362015 @default.
• W2099694536 countsByYear W20996945362016 @default.
• W2099694536 countsByYear W20996945362017 @default.
• W2099694536 countsByYear W20996945362018 @default.
• W2099694536 countsByYear W20996945362020 @default.
• W2099694536 countsByYear W20996945362021 @default.
• W2099694536 crossrefType "journal-article" @default.
• W2099694536 hasAuthorship W2099694536A5011259402 @default.
• W2099694536 hasAuthorship W2099694536A5048615839 @default.
• W2099694536 hasAuthorship W2099694536A5057519121 @default.
• W2099694536 hasAuthorship W2099694536A5058902481 @default.
• W2099694536 hasConcept C104317684 @default.
• W2099694536 hasConcept C122735190 @default.
• W2099694536 hasConcept C21249469 @default.
• W2099694536 hasConcept C30481170 @default.
• W2099694536 hasConcept C54355233 @default.
• W2099694536 hasConcept C69991583 @default.
• W2099694536 hasConcept C72472911 @default.
• W2099694536 hasConcept C76725341 @default.
• W2099694536 hasConcept C81941488 @default.
• W2099694536 hasConcept C86803240 @default.
• W2099694536 hasConceptScore W2099694536C104317684 @default.
• W2099694536 hasConceptScore W2099694536C122735190 @default.
• W2099694536 hasConceptScore W2099694536C21249469 @default.
• W2099694536 hasConceptScore W2099694536C30481170 @default.
• W2099694536 hasConceptScore W2099694536C54355233 @default.
• W2099694536 hasConceptScore W2099694536C69991583 @default.
• W2099694536 hasConceptScore W2099694536C72472911 @default.
• W2099694536 hasConceptScore W2099694536C76725341 @default.
• W2099694536 hasConceptScore W2099694536C81941488 @default.
• W2099694536 hasConceptScore W2099694536C86803240 @default.
• W2099694536 hasIssue "1" @default.
• W2099694536 hasLocation W20996945361 @default.
• W2099694536 hasLocation W20996945362 @default.
• W2099694536 hasOpenAccess W2099694536 @default.
• W2099694536 hasPrimaryLocation W20996945361 @default.
• W2099694536 hasRelatedWork W1535114875 @default.
• W2099694536 hasRelatedWork W1543573112 @default.
• W2099694536 hasRelatedWork W1573319237 @default.
• W2099694536 hasRelatedWork W1975293247 @default.
• W2099694536 hasRelatedWork W1996810298 @default.
• W2099694536 hasRelatedWork W2018900847 @default.
• W2099694536 hasRelatedWork W2075693647 @default.
• W2099694536 hasRelatedWork W2099694536 @default.

• next