FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099695941> ?p ?o ?g. }

• W2099695941 abstract "Hepatitis C virus (HCV), the sole member of the Hepacivirus genus of the Flaviviridae family, is an enveloped virus with a positive-sense single-stranded RNA genome of 9600 nucleotides. HCV virions mainly infect hepatocytes, entering via specific receptors and clathrin-mediated endocytosis to release their genome from acidified endosomes.1 Over 170 million people worldwide are infected with HCV, and 80–85% of these develop chronic hepatitis C, which in a sizeable portion (up to 20%) leads to cirrhosis, hepatic failure or hepatocellular carcinoma. Current HCV treatment is based on the antiviral action of interferon α (IFNα) in combination with ribavirin, although this clears the virus in only 40–55% of patients.IFNα plays a central role in the innate immune system by inducing an antiviral state in target cells,2 most notably for HCV by inhibiting viral replication.3 However, it is less clear whether IFNα initiates specific actions to limit HCV infections, such as restricting virion attachment and/or entry into hepatocytes. In this edition of Gut ( see page 10.1136/gut.2006.111443 ), Murao et al 4 demonstrate in vitro that IFNα decreases cell surface expression of scavenger receptor class B type I (SR-BI), a pivotal molecule in early stages of the HCV life cycle. Before discussing their findings, however, we first describe the molecular ensemble of host cellular factors which orchestrate HCV entry.Until the last decade, HCV research was hampered by lack of infectious clones and an inability to propagate the virus in cultured liver cells. Introduction of the HCV replicon system (a self-replicating subgenomic construct)5 allowed studies of viral replication, …" @default.
• W2099695941 created "2016-06-24" @default.
• W2099695941 creator A5019658830 @default.
• W2099695941 creator A5062229418 @default.
• W2099695941 date "2008-04-11" @default.
• W2099695941 modified "2023-09-26" @default.
• W2099695941 title "How does interferon inhibit HCV cell entry?" @default.
• W2099695941 cites W1862446821 @default.
• W2099695941 cites W1967244561 @default.
• W2099695941 cites W1980843025 @default.
• W2099695941 cites W1985170971 @default.
• W2099695941 cites W1986464076 @default.
• W2099695941 cites W1991443329 @default.
• W2099695941 cites W2001771411 @default.
• W2099695941 cites W2003579943 @default.
• W2099695941 cites W2014049842 @default.
• W2099695941 cites W2015489330 @default.
• W2099695941 cites W2026956555 @default.
• W2099695941 cites W2042994480 @default.
• W2099695941 cites W2043832254 @default.
• W2099695941 cites W2044193462 @default.
• W2099695941 cites W2049107903 @default.
• W2099695941 cites W2067214744 @default.
• W2099695941 cites W2072661041 @default.
• W2099695941 cites W2075147482 @default.
• W2099695941 cites W2091328306 @default.
• W2099695941 cites W2103565638 @default.
• W2099695941 cites W2105291849 @default.
• W2099695941 cites W2110842901 @default.
• W2099695941 cites W2116134699 @default.
• W2099695941 cites W2122963133 @default.
• W2099695941 cites W2126153046 @default.
• W2099695941 cites W2130661443 @default.
• W2099695941 cites W2140799443 @default.
• W2099695941 cites W2141626800 @default.
• W2099695941 cites W2147126871 @default.
• W2099695941 cites W2149951088 @default.
• W2099695941 cites W2151898297 @default.
• W2099695941 cites W2154698511 @default.
• W2099695941 cites W2160174559 @default.
• W2099695941 cites W2172002207 @default.
• W2099695941 doi "https://doi.org/10.1136/gut.2007.143131" @default.
• W2099695941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18408099" @default.
• W2099695941 hasPublicationYear "2008" @default.
• W2099695941 type Work @default.
• W2099695941 sameAs 2099695941 @default.
• W2099695941 citedByCount "0" @default.
• W2099695941 crossrefType "journal-article" @default.
• W2099695941 hasAuthorship W2099695941A5019658830 @default.
• W2099695941 hasAuthorship W2099695941A5062229418 @default.
• W2099695941 hasConcept C136449434 @default.
• W2099695941 hasConcept C140704245 @default.
• W2099695941 hasConcept C159047783 @default.
• W2099695941 hasConcept C203014093 @default.
• W2099695941 hasConcept C2522874641 @default.
• W2099695941 hasConcept C2776178377 @default.
• W2099695941 hasConcept C2776408679 @default.
• W2099695941 hasConcept C2776455275 @default.
• W2099695941 hasConcept C2777510210 @default.
• W2099695941 hasConcept C2781463415 @default.
• W2099695941 hasConcept C58475186 @default.
• W2099695941 hasConcept C86803240 @default.
• W2099695941 hasConcept C8891405 @default.
• W2099695941 hasConceptScore W2099695941C136449434 @default.
• W2099695941 hasConceptScore W2099695941C140704245 @default.
• W2099695941 hasConceptScore W2099695941C159047783 @default.
• W2099695941 hasConceptScore W2099695941C203014093 @default.
• W2099695941 hasConceptScore W2099695941C2522874641 @default.
• W2099695941 hasConceptScore W2099695941C2776178377 @default.
• W2099695941 hasConceptScore W2099695941C2776408679 @default.
• W2099695941 hasConceptScore W2099695941C2776455275 @default.
• W2099695941 hasConceptScore W2099695941C2777510210 @default.
• W2099695941 hasConceptScore W2099695941C2781463415 @default.
• W2099695941 hasConceptScore W2099695941C58475186 @default.
• W2099695941 hasConceptScore W2099695941C86803240 @default.
• W2099695941 hasConceptScore W2099695941C8891405 @default.
• W2099695941 hasLocation W20996959411 @default.
• W2099695941 hasLocation W20996959412 @default.
• W2099695941 hasOpenAccess W2099695941 @default.
• W2099695941 hasPrimaryLocation W20996959411 @default.
• W2099695941 hasRelatedWork W1502548685 @default.
• W2099695941 hasRelatedWork W157731219 @default.
• W2099695941 hasRelatedWork W1966967317 @default.
• W2099695941 hasRelatedWork W1972503143 @default.
• W2099695941 hasRelatedWork W1990049339 @default.
• W2099695941 hasRelatedWork W2001115136 @default.
• W2099695941 hasRelatedWork W2017947620 @default.
• W2099695941 hasRelatedWork W2021389414 @default.
• W2099695941 hasRelatedWork W2025939083 @default.
• W2099695941 hasRelatedWork W2047352444 @default.
• W2099695941 hasRelatedWork W2050027918 @default.
• W2099695941 hasRelatedWork W2066203226 @default.
• W2099695941 hasRelatedWork W2077168230 @default.
• W2099695941 hasRelatedWork W2108616113 @default.
• W2099695941 hasRelatedWork W2128515651 @default.
• W2099695941 hasRelatedWork W2140816592 @default.
• W2099695941 hasRelatedWork W2143671051 @default.
• W2099695941 hasRelatedWork W2405270531 @default.
• W2099695941 hasRelatedWork W2106558241 @default.
• W2099695941 hasRelatedWork W3141637466 @default.

• next