FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099696543> ?p ?o ?g. }

• W2099696543 endingPage "6" @default.
• W2099696543 startingPage "4931" @default.
• W2099696543 abstract "A monoclonal antibody, designated 3.2.3, which recognizes a novel Mr 60,000 disulfide-linked lytic triggering structure present on rat large granular lymphocytes and natural killer (NK) cells was recently described (W. H. Chambers et al., J. Exp. Med., 169: 1373-1389, 1989). The present study describes the use of 3.2.3 to identify the in situ tissue distribution of large granular lymphocytes/NK cells in different organs from normal and tumor-bearing F344 rats. Frozen tissue sections were prepared and stained with monoclonal antibody 3.2.3 using an avidinbiotin immunoperoxidase technique. 3.2.3+ NK cells were easily identified using this technique, and quantitative analysis of various tissues of normal rats demonstrated that (a) in the spleen, most NK cells were located, sometimes as aggregates, in the red pulp (12.4% of total nucleated cells in that organ compartment) with relatively few noted in the white pulp (0.2-2.3%); (b) in the liver, 3.2.3+ cells were rare, sparsely distributed, and located primarily in the sinusoids (1.2%); (c) in the lungs, 3.2.3+ cells were located in the interstitium (3.7%); (d) in the thymus, 3.2.3+ cells were found primarily in the medulla (1.8%) adjacent to the cortex but not in the cortex itself (0.2%); (e) in the lymph node, most 3.2.3+ cells were contained in the paracortex (6.9%); and finally (f) in the small bowel, 3.2.3+ cells were present in the lamina propria (8.6%) and as aggregates in the interfollicular zone of Peyer's patches (0.7%). To study the distribution of 3.2.3+ NK cells in developing tumor metastases, we induced liver metastases by intrasplenic injection of MADB106 mammary adenocarcinoma cells and prepared frozen tissue sections of the liver 10-14 days later. We found that the frequency of 3.2.3+ cells in the developing liver metastases was 3-6 times higher than in the surrounding normal liver tissue. Moreover, the frequency of 3.2.3+ NK cells was equivalent to the frequency of tumor-infiltrating CD5+ T-cells identified in the same tumor lesions. This suggests specific infiltration of 3.2.3+ NK cells in early developing metastatic lesions. These results indicate that monoclonal antibody 3.2.3 will be valuable in analyzing the involvement of NK cells in various pathological states." @default.
• W2099696543 created "2016-06-24" @default.
• W2099696543 creator A5003503263 @default.
• W2099696543 creator A5025116664 @default.
• W2099696543 creator A5075501671 @default.
• W2099696543 creator A5078466417 @default.
• W2099696543 date "1991-09-15" @default.
• W2099696543 modified "2023-10-17" @default.
• W2099696543 title "In situ localization of 3.2.3+ natural killer cells in tissues from normal and tumor-bearing rats." @default.
• W2099696543 cites W1499779422 @default.
• W2099696543 cites W1532230742 @default.
• W2099696543 cites W1534916753 @default.
• W2099696543 cites W1543285514 @default.
• W2099696543 cites W1556867369 @default.
• W2099696543 cites W1563878105 @default.
• W2099696543 cites W1922974839 @default.
• W2099696543 cites W1943657748 @default.
• W2099696543 cites W1977445270 @default.
• W2099696543 cites W1983299898 @default.
• W2099696543 cites W1999381809 @default.
• W2099696543 cites W2019007239 @default.
• W2099696543 cites W2027115443 @default.
• W2099696543 cites W2044333992 @default.
• W2099696543 cites W2063820933 @default.
• W2099696543 cites W2068602959 @default.
• W2099696543 cites W2069079578 @default.
• W2099696543 cites W2076617145 @default.
• W2099696543 cites W2084093106 @default.
• W2099696543 cites W2092869512 @default.
• W2099696543 cites W2133800868 @default.
• W2099696543 cites W2144931720 @default.
• W2099696543 cites W2147145702 @default.
• W2099696543 cites W2147787458 @default.
• W2099696543 cites W2157528499 @default.
• W2099696543 cites W2177985207 @default.
• W2099696543 cites W2329211716 @default.
• W2099696543 cites W2337954569 @default.
• W2099696543 cites W2343541789 @default.
• W2099696543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1893382" @default.
• W2099696543 hasPublicationYear "1991" @default.
• W2099696543 type Work @default.
• W2099696543 sameAs 2099696543 @default.
• W2099696543 citedByCount "15" @default.
• W2099696543 countsByYear W20996965432012 @default.
• W2099696543 countsByYear W20996965432014 @default.
• W2099696543 crossrefType "journal-article" @default.
• W2099696543 hasAuthorship W2099696543A5003503263 @default.
• W2099696543 hasAuthorship W2099696543A5025116664 @default.
• W2099696543 hasAuthorship W2099696543A5075501671 @default.
• W2099696543 hasAuthorship W2099696543A5078466417 @default.
• W2099696543 hasConcept C128102431 @default.
• W2099696543 hasConcept C142724271 @default.
• W2099696543 hasConcept C153911025 @default.
• W2099696543 hasConcept C159654299 @default.
• W2099696543 hasConcept C181152851 @default.
• W2099696543 hasConcept C185592680 @default.
• W2099696543 hasConcept C203014093 @default.
• W2099696543 hasConcept C2777092883 @default.
• W2099696543 hasConcept C2777310793 @default.
• W2099696543 hasConcept C2778232189 @default.
• W2099696543 hasConcept C2780849966 @default.
• W2099696543 hasConcept C2780931953 @default.
• W2099696543 hasConcept C529295009 @default.
• W2099696543 hasConcept C542903549 @default.
• W2099696543 hasConcept C71924100 @default.
• W2099696543 hasConcept C86803240 @default.
• W2099696543 hasConcept C95798472 @default.
• W2099696543 hasConceptScore W2099696543C128102431 @default.
• W2099696543 hasConceptScore W2099696543C142724271 @default.
• W2099696543 hasConceptScore W2099696543C153911025 @default.
• W2099696543 hasConceptScore W2099696543C159654299 @default.
• W2099696543 hasConceptScore W2099696543C181152851 @default.
• W2099696543 hasConceptScore W2099696543C185592680 @default.
• W2099696543 hasConceptScore W2099696543C203014093 @default.
• W2099696543 hasConceptScore W2099696543C2777092883 @default.
• W2099696543 hasConceptScore W2099696543C2777310793 @default.
• W2099696543 hasConceptScore W2099696543C2778232189 @default.
• W2099696543 hasConceptScore W2099696543C2780849966 @default.
• W2099696543 hasConceptScore W2099696543C2780931953 @default.
• W2099696543 hasConceptScore W2099696543C529295009 @default.
• W2099696543 hasConceptScore W2099696543C542903549 @default.
• W2099696543 hasConceptScore W2099696543C71924100 @default.
• W2099696543 hasConceptScore W2099696543C86803240 @default.
• W2099696543 hasConceptScore W2099696543C95798472 @default.
• W2099696543 hasIssue "18" @default.
• W2099696543 hasLocation W20996965431 @default.
• W2099696543 hasOpenAccess W2099696543 @default.
• W2099696543 hasPrimaryLocation W20996965431 @default.
• W2099696543 hasRelatedWork W2063415405 @default.
• W2099696543 hasRelatedWork W2077898287 @default.
• W2099696543 hasRelatedWork W2099696543 @default.
• W2099696543 hasRelatedWork W2155414801 @default.
• W2099696543 hasRelatedWork W2319591505 @default.
• W2099696543 hasRelatedWork W2323673960 @default.
• W2099696543 hasRelatedWork W2384786599 @default.
• W2099696543 hasRelatedWork W274975866 @default.
• W2099696543 hasRelatedWork W2972856050 @default.
• W2099696543 hasRelatedWork W3201391573 @default.

• next