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• W2099697717 startingPage "445" @default.
• W2099697717 abstract "Epidemiological evidence strongly suggests an association between cigarette smoking and pancreatic diseases. It is well recognized that nicotine, a major component in cigarette smoke, is an addictive agent and, therefore, reinforces smoking behavior. The current review update focuses on the genetics of nicotine dependence and its role on the development of pancreatic diseases. The role of smoking and nicotine in pancreatitis and pancreatic cancer development is also discussed. Exposure of laboratory animals to nicotine clearly supports the notion that nicotine can induce pancreatic injury. The mechanism by which nicotine induces such effects is perhaps mediated via signal transduction pathways in the pancreatic acinar cell, leading to enhanced levels of intracellular calcium release, resulting in cytotoxicity and eventual cell death. The induction of pancreatic injury by nicotine may also involve activation and expression of protooncogene, H-ras, which can increase cytosolic calcium via second messenger pathways. Development of pancreatic carcinoma in cigarette smokers as observed in human populations may be the result of activation and mutation of the H-ras gene. A possible pathogenetic mechanism of nicotine in the pancreas activating multiple signal transduction pathways is schematically summarized in Figure 1." @default.
• W2099697717 created "2016-06-24" @default.
• W2099697717 creator A5015772173 @default.
• W2099697717 creator A5060744783 @default.
• W2099697717 creator A5064064080 @default.
• W2099697717 creator A5082611056 @default.
• W2099697717 date "2002-07-01" @default.
• W2099697717 modified "2023-10-14" @default.
• W2099697717 title "Pathophysiological Effects of Nicotine on the Pancreas: An Update" @default.
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