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- W2099698731 endingPage "1124" @default.
- W2099698731 startingPage "1109" @default.
- W2099698731 abstract "To develop a comprehensive catalogue of phenotypic and functional parameters of human CD4(+) T cell differentiation stages, we have performed microarray gene expression profiling on subpopulations of human thymocytes and circulating naive CD4(+) T cells, including CD3(-)CD4(+)CD8(-) intrathymic T progenitor cells, CD3(int)CD4(+)CD8(+) 'double positive' thymocytes, CD3(high)CD4(+)CD8(-) 'single positive' thymocytes, CD3(+)CD4(+)CD8(-) CD45RA(+)CD62L(+) naive T cells from cord blood and CD3(+)CD4(+)CD8(-) CD45RA(+)CD62L(+) naive T cells from adult blood. These subpopulations were sort-purified to >98% purity and their expressed RNAs were analyzed on Affymetrix Human Genome U133 arrays. Comparison of gene expression signals between these subpopulations and with early passage fetal thymic stromal cultures identify: (i) transcripts that are preferentially expressed in human CD4(+) T cell subpopulations and not in thymic stromal cells; (ii) major shifts in gene expression as progenitor T cells mature into progeny; (iii) preferential expression of transcripts at the progenitor cell stage with plausible relevance to the regulation of expansion and differentiation of these cells; and (iv) preferential expression of potential markers of recent thymic emigrants in naive-phenotype CD4(+) T cells from cord blood. Further evaluation of these findings may lead to a better definition of human thymopoiesis as well as to improved approaches to monitor and to augment the function of this important organ of T cell production." @default.
- W2099698731 created "2016-06-24" @default.
- W2099698731 creator A5006216510 @default.
- W2099698731 creator A5063919862 @default.
- W2099698731 creator A5063972221 @default.
- W2099698731 creator A5076437068 @default.
- W2099698731 creator A5089879479 @default.
- W2099698731 date "2004-06-21" @default.
- W2099698731 modified "2023-10-10" @default.
- W2099698731 title "Gene expression profiles during human CD4+ T cell differentiation" @default.
- W2099698731 cites W135988341 @default.
- W2099698731 cites W1499223322 @default.
- W2099698731 cites W1510178802 @default.
- W2099698731 cites W1533283205 @default.
- W2099698731 cites W1537791144 @default.
- W2099698731 cites W1566958588 @default.
- W2099698731 cites W1580217007 @default.
- W2099698731 cites W1600928734 @default.
- W2099698731 cites W1626388077 @default.
- W2099698731 cites W1633460951 @default.
- W2099698731 cites W1678352491 @default.
- W2099698731 cites W1779929551 @default.
- W2099698731 cites W1899752912 @default.
- W2099698731 cites W1937347519 @default.
- W2099698731 cites W1962685102 @default.
- W2099698731 cites W1963627373 @default.
- W2099698731 cites W1963913202 @default.
- W2099698731 cites W1963984954 @default.
- W2099698731 cites W1965971815 @default.
- W2099698731 cites W1966344619 @default.
- W2099698731 cites W1967994686 @default.
- W2099698731 cites W1972426382 @default.
- W2099698731 cites W1972776583 @default.
- W2099698731 cites W1975087118 @default.
- W2099698731 cites W1977233573 @default.
- W2099698731 cites W1980044885 @default.
- W2099698731 cites W1986336454 @default.
- W2099698731 cites W1989645452 @default.
- W2099698731 cites W1992438206 @default.
- W2099698731 cites W1992504446 @default.
- W2099698731 cites W1993778689 @default.
- W2099698731 cites W1996605553 @default.
- W2099698731 cites W1996713852 @default.
- W2099698731 cites W1996822762 @default.
- W2099698731 cites W1997361579 @default.
- W2099698731 cites W1997855401 @default.
- W2099698731 cites W1999582446 @default.
- W2099698731 cites W2004668797 @default.
- W2099698731 cites W2005273809 @default.
- W2099698731 cites W2009259569 @default.
- W2099698731 cites W2014686737 @default.
- W2099698731 cites W2016460940 @default.
- W2099698731 cites W2016836061 @default.
- W2099698731 cites W2022157262 @default.
- W2099698731 cites W2026802569 @default.
- W2099698731 cites W2027162867 @default.
- W2099698731 cites W2028669354 @default.
- W2099698731 cites W2033904138 @default.
- W2099698731 cites W2037951817 @default.
- W2099698731 cites W2038173050 @default.
- W2099698731 cites W2038437697 @default.
- W2099698731 cites W2039269834 @default.
- W2099698731 cites W2039666046 @default.
- W2099698731 cites W2045381913 @default.
- W2099698731 cites W2046648030 @default.
- W2099698731 cites W2052068595 @default.
- W2099698731 cites W2052110444 @default.
- W2099698731 cites W2052453105 @default.
- W2099698731 cites W2054507865 @default.
- W2099698731 cites W2055873401 @default.
- W2099698731 cites W2058012195 @default.
- W2099698731 cites W2059239713 @default.
- W2099698731 cites W2059339710 @default.
- W2099698731 cites W2059642781 @default.
- W2099698731 cites W2059990422 @default.
- W2099698731 cites W2065541632 @default.
- W2099698731 cites W2066433054 @default.
- W2099698731 cites W2067761476 @default.
- W2099698731 cites W2076894266 @default.
- W2099698731 cites W2077073183 @default.
- W2099698731 cites W2079749432 @default.
- W2099698731 cites W2079849140 @default.
- W2099698731 cites W2083443411 @default.
- W2099698731 cites W2083612980 @default.
- W2099698731 cites W2085091366 @default.
- W2099698731 cites W2086132113 @default.
- W2099698731 cites W2086267296 @default.
- W2099698731 cites W2087243137 @default.
- W2099698731 cites W2089092115 @default.
- W2099698731 cites W2093656658 @default.
- W2099698731 cites W2095321474 @default.
- W2099698731 cites W2096632716 @default.
- W2099698731 cites W2097925286 @default.
- W2099698731 cites W2098409714 @default.
- W2099698731 cites W2104259190 @default.
- W2099698731 cites W2108212727 @default.
- W2099698731 cites W2109972881 @default.
- W2099698731 cites W2111305451 @default.