FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099699832> ?p ?o ?g. }

• W2099699832 endingPage "43" @default.
• W2099699832 startingPage "337" @default.
• W2099699832 abstract "Regulatory T cells (Tregs) play an important role in immunological self-tolerance and protect the host from autoimmune disease. However, in cancer immunity, Tregs might block anti-tumor immune responses. Therefore, the depletion of Tregs using a specific agent that suppresses its function or population, such as an anti-CD25 antibody, could promote anti-tumor immune responses. In the present study, a cytotoxicity assay, enzyme-linked immunosorbent spot (ELISPOT) assay and measuring cytokine secretion, were used to study the efficacy of Treg depletion by anti-CD25 antibody added to a dendritic cell/tumor cell (DC/TC) fusion hybrid vaccine in a murine pancreatic cancer model. All the mice treated with the combined therapy of fusion hybrid vaccine and Treg depletion rejected tumor growth in a challenging test, although the rejection rate was 20% both for mice that received the fusion hybrids alone or Treg depletion alone. In addition, combined therapy showed a significantly improved survival in comparison to other treatment or control groups. The NK cell activity for DC/TC fusion + Treg depletion was significantly higher than that for the other treatment groups. Cytotoxic T lymphocyte (CTL) activity for DC/TC could potentially be enhanced by the addition of Treg depletion therapy. The treatments including DC/TC fusion induced IFN-gamma secreting effector cells in ELISPOT assays. Furthermore, a cytometric beads array assay used to measure cytokine secretion showed that DC/TC fusion + Treg depletion stimulated the highest levels of IFN-gamma Th1/Th2 ratios and Th17. These results demonstrate that Treg depletion combined with DC/TC fusion hybrid vaccine enhanced the efficacy of immunotherapy in pancreatic cancer by activating CTLs and NK cells." @default.
• W2099699832 created "2016-06-24" @default.
• W2099699832 creator A5004532337 @default.
• W2099699832 creator A5008002384 @default.
• W2099699832 creator A5019586725 @default.
• W2099699832 creator A5021221175 @default.
• W2099699832 creator A5035758142 @default.
• W2099699832 creator A5038406201 @default.
• W2099699832 creator A5047822588 @default.
• W2099699832 creator A5057313515 @default.
• W2099699832 creator A5083431844 @default.
• W2099699832 creator A5091140143 @default.
• W2099699832 date "2009-08-01" @default.
• W2099699832 modified "2023-09-23" @default.
• W2099699832 title "Enhancement of anti-tumor immunity by high levels of Th1 and Th17 with a combination of dendritic cell fusion hybrids and regulatory T cell depletion in pancreatic cancer." @default.
• W2099699832 cites W1484295404 @default.
• W2099699832 cites W1491508553 @default.
• W2099699832 cites W1985956263 @default.
• W2099699832 cites W2019060341 @default.
• W2099699832 cites W2022300217 @default.
• W2099699832 cites W2027741075 @default.
• W2099699832 cites W2030577394 @default.
• W2099699832 cites W2049698602 @default.
• W2099699832 cites W2055522356 @default.
• W2099699832 cites W2059864992 @default.
• W2099699832 cites W2061445083 @default.
• W2099699832 cites W2063982677 @default.
• W2099699832 cites W2074229115 @default.
• W2099699832 cites W2075012280 @default.
• W2099699832 cites W2076819781 @default.
• W2099699832 cites W2081451656 @default.
• W2099699832 cites W2092235636 @default.
• W2099699832 cites W2098367656 @default.
• W2099699832 cites W2111876649 @default.
• W2099699832 cites W2113190700 @default.
• W2099699832 cites W2114140047 @default.
• W2099699832 cites W2115346550 @default.
• W2099699832 cites W2116201625 @default.
• W2099699832 cites W2138163780 @default.
• W2099699832 cites W2139191751 @default.
• W2099699832 cites W2148226248 @default.
• W2099699832 cites W2154041075 @default.
• W2099699832 cites W2162819001 @default.
• W2099699832 cites W2163040415 @default.
• W2099699832 cites W2167307395 @default.
• W2099699832 cites W2177327503 @default.
• W2099699832 cites W2772222670 @default.
• W2099699832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19578774" @default.
• W2099699832 hasPublicationYear "2009" @default.
• W2099699832 type Work @default.
• W2099699832 sameAs 2099699832 @default.
• W2099699832 citedByCount "25" @default.
• W2099699832 countsByYear W20996998322012 @default.
• W2099699832 countsByYear W20996998322013 @default.
• W2099699832 countsByYear W20996998322015 @default.
• W2099699832 countsByYear W20996998322016 @default.
• W2099699832 countsByYear W20996998322017 @default.
• W2099699832 countsByYear W20996998322019 @default.
• W2099699832 countsByYear W20996998322022 @default.
• W2099699832 crossrefType "journal-article" @default.
• W2099699832 hasAuthorship W2099699832A5004532337 @default.
• W2099699832 hasAuthorship W2099699832A5008002384 @default.
• W2099699832 hasAuthorship W2099699832A5019586725 @default.
• W2099699832 hasAuthorship W2099699832A5021221175 @default.
• W2099699832 hasAuthorship W2099699832A5035758142 @default.
• W2099699832 hasAuthorship W2099699832A5038406201 @default.
• W2099699832 hasAuthorship W2099699832A5047822588 @default.
• W2099699832 hasAuthorship W2099699832A5057313515 @default.
• W2099699832 hasAuthorship W2099699832A5083431844 @default.
• W2099699832 hasAuthorship W2099699832A5091140143 @default.
• W2099699832 hasConcept C147969180 @default.
• W2099699832 hasConcept C154317977 @default.
• W2099699832 hasConcept C167672396 @default.
• W2099699832 hasConcept C202751555 @default.
• W2099699832 hasConcept C203014093 @default.
• W2099699832 hasConcept C2776090121 @default.
• W2099699832 hasConcept C2777701055 @default.
• W2099699832 hasConcept C2778170410 @default.
• W2099699832 hasConcept C2778296632 @default.
• W2099699832 hasConcept C2779053233 @default.
• W2099699832 hasConcept C502942594 @default.
• W2099699832 hasConcept C55493867 @default.
• W2099699832 hasConcept C79484868 @default.
• W2099699832 hasConcept C86803240 @default.
• W2099699832 hasConcept C8891405 @default.
• W2099699832 hasConceptScore W2099699832C147969180 @default.
• W2099699832 hasConceptScore W2099699832C154317977 @default.
• W2099699832 hasConceptScore W2099699832C167672396 @default.
• W2099699832 hasConceptScore W2099699832C202751555 @default.
• W2099699832 hasConceptScore W2099699832C203014093 @default.
• W2099699832 hasConceptScore W2099699832C2776090121 @default.
• W2099699832 hasConceptScore W2099699832C2777701055 @default.
• W2099699832 hasConceptScore W2099699832C2778170410 @default.
• W2099699832 hasConceptScore W2099699832C2778296632 @default.
• W2099699832 hasConceptScore W2099699832C2779053233 @default.
• W2099699832 hasConceptScore W2099699832C502942594 @default.
• W2099699832 hasConceptScore W2099699832C55493867 @default.
• W2099699832 hasConceptScore W2099699832C79484868 @default.

• next