FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099702016> ?p ?o ?g. }

• W2099702016 endingPage "649" @default.
• W2099702016 startingPage "637" @default.
• W2099702016 abstract "Contact between sister chromatids from S phase to anaphase depends on cohesin, a large multi-subunit protein complex. Mutations in sister chromatid cohesion proteins underlie the human developmental condition, Cornelia de Lange syndrome. Roles for cohesin in regulating gene expression, sometimes in combination with CCCTC-binding factor (CTCF), have emerged. We analyzed zebrafish embryos null for cohesin subunit rad21 using microarrays to determine global effects of cohesin on gene expression during embryogenesis. This identified Rad21-associated gene networks that included myca (zebrafish c-myc), p53 and mdm2. In zebrafish, cohesin binds to the transcription start sites of p53 and mdm2, and depletion of either Rad21 or CTCF increased their transcription. In contrast, myca expression was strongly downregulated upon loss of Rad21 while depletion of CTCF had little effect. Depletion of Rad21 or the cohesin-loading factor Nipped-B in Drosophila cells also reduced expression of myc and Myc target genes. Cohesin bound the transcription start site plus an upstream predicted CTCF binding site at zebrafish myca. Binding and positive regulation of the c-Myc gene by cohesin is conserved through evolution, indicating that this regulation is likely to be direct. The exact mechanism of regulation is unknown, but local changes in histone modification associated with transcription repression at the myca gene were observed in rad21 mutants." @default.
• W2099702016 created "2016-06-24" @default.
• W2099702016 creator A5022111438 @default.
• W2099702016 creator A5043323992 @default.
• W2099702016 creator A5062234987 @default.
• W2099702016 creator A5063404487 @default.
• W2099702016 creator A5071795589 @default.
• W2099702016 creator A5075395238 @default.
• W2099702016 creator A5079814428 @default.
• W2099702016 creator A5081382969 @default.
• W2099702016 creator A5086269774 @default.
• W2099702016 date "2010-08-01" @default.
• W2099702016 modified "2023-10-14" @default.
• W2099702016 title "Positive regulation of c-Myc by cohesin is direct, and evolutionarily conserved" @default.
• W2099702016 cites W1963821249 @default.
• W2099702016 cites W1965636994 @default.
• W2099702016 cites W1971933096 @default.
• W2099702016 cites W1972307085 @default.
• W2099702016 cites W1973342161 @default.
• W2099702016 cites W1975403665 @default.
• W2099702016 cites W1976874039 @default.
• W2099702016 cites W1977632740 @default.
• W2099702016 cites W1977752183 @default.
• W2099702016 cites W1983579777 @default.
• W2099702016 cites W1989391941 @default.
• W2099702016 cites W1992476706 @default.
• W2099702016 cites W1993426520 @default.
• W2099702016 cites W2000825723 @default.
• W2099702016 cites W2019077723 @default.
• W2099702016 cites W2020027399 @default.
• W2099702016 cites W2021654829 @default.
• W2099702016 cites W2027352426 @default.
• W2099702016 cites W2028022357 @default.
• W2099702016 cites W2029215616 @default.
• W2099702016 cites W2030222772 @default.
• W2099702016 cites W2031114253 @default.
• W2099702016 cites W2034719507 @default.
• W2099702016 cites W2043028159 @default.
• W2099702016 cites W2047005748 @default.
• W2099702016 cites W2059171091 @default.
• W2099702016 cites W2062088534 @default.
• W2099702016 cites W2065794410 @default.
• W2099702016 cites W2067471138 @default.
• W2099702016 cites W2070810538 @default.
• W2099702016 cites W2071051659 @default.
• W2099702016 cites W2073493772 @default.
• W2099702016 cites W2090117717 @default.
• W2099702016 cites W2091151146 @default.
• W2099702016 cites W2092752178 @default.
• W2099702016 cites W2100995605 @default.
• W2099702016 cites W2103117539 @default.
• W2099702016 cites W2110691960 @default.
• W2099702016 cites W2111320259 @default.
• W2099702016 cites W2114416970 @default.
• W2099702016 cites W2115919623 @default.
• W2099702016 cites W2116188114 @default.
• W2099702016 cites W2117177914 @default.
• W2099702016 cites W2119006560 @default.
• W2099702016 cites W2128483455 @default.
• W2099702016 cites W2128963466 @default.
• W2099702016 cites W2130155683 @default.
• W2099702016 cites W2132024988 @default.
• W2099702016 cites W2133821553 @default.
• W2099702016 cites W2139091482 @default.
• W2099702016 cites W2149141811 @default.
• W2099702016 cites W2154457034 @default.
• W2099702016 cites W2155792198 @default.
• W2099702016 cites W2157131586 @default.
• W2099702016 cites W2157214001 @default.
• W2099702016 cites W2159827301 @default.
• W2099702016 cites W2161234257 @default.
• W2099702016 cites W2165584097 @default.
• W2099702016 cites W2169321817 @default.
• W2099702016 doi "https://doi.org/10.1016/j.ydbio.2010.05.493" @default.
• W2099702016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2941799" @default.
• W2099702016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20553708" @default.
• W2099702016 hasPublicationYear "2010" @default.
• W2099702016 type Work @default.
• W2099702016 sameAs 2099702016 @default.
• W2099702016 citedByCount "94" @default.
• W2099702016 countsByYear W20997020162012 @default.
• W2099702016 countsByYear W20997020162013 @default.
• W2099702016 countsByYear W20997020162014 @default.
• W2099702016 countsByYear W20997020162015 @default.
• W2099702016 countsByYear W20997020162016 @default.
• W2099702016 countsByYear W20997020162017 @default.
• W2099702016 countsByYear W20997020162018 @default.
• W2099702016 countsByYear W20997020162019 @default.
• W2099702016 countsByYear W20997020162020 @default.
• W2099702016 countsByYear W20997020162021 @default.
• W2099702016 countsByYear W20997020162022 @default.
• W2099702016 countsByYear W20997020162023 @default.
• W2099702016 crossrefType "journal-article" @default.
• W2099702016 hasAuthorship W2099702016A5022111438 @default.
• W2099702016 hasAuthorship W2099702016A5043323992 @default.
• W2099702016 hasAuthorship W2099702016A5062234987 @default.
• W2099702016 hasAuthorship W2099702016A5063404487 @default.
• W2099702016 hasAuthorship W2099702016A5071795589 @default.

• next