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• W2099721805 abstract "The landmark completion of the Leishmania major genome sequence and the recent publication of the L. infantum and L. braziliensis genomes revealed the surprising result that, although separated by 15–50 million years of evolution, the Leishmania genomes are highly conserved and have less than 1% species-specific genes. Yet, these three species of Leishmania cause distinctive and diverse diseases in humans. Here, we discuss these findings together with recent microarray and proteomics studies and highlight their importance in understanding Leishmania disease phenotypes. The landmark completion of the Leishmania major genome sequence and the recent publication of the L. infantum and L. braziliensis genomes revealed the surprising result that, although separated by 15–50 million years of evolution, the Leishmania genomes are highly conserved and have less than 1% species-specific genes. Yet, these three species of Leishmania cause distinctive and diverse diseases in humans. Here, we discuss these findings together with recent microarray and proteomics studies and highlight their importance in understanding Leishmania disease phenotypes." @default.
• W2099721805 created "2016-06-24" @default.
• W2099721805 creator A5061207950 @default.
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• W2099721805 date "2008-03-01" @default.
• W2099721805 modified "2023-10-16" @default.
• W2099721805 title "Leishmania: conserved evolution – diverse diseases" @default.
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• W2099721805 doi "https://doi.org/10.1016/j.pt.2007.11.006" @default.
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