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• W2099724688 abstract "Low and high-grade ductal carcinoma in-situ (DCIS) are known to be highly disparate by a multitude of parameters, including progression potential, immunophenotype, gene expression profile and DNA ploidy. In this study, we analyzed a group of intermediate and high-grade DCIS cases to determine how well the core biopsy predicts the maximal pathology in the associated excisions, and to determine if there are any core biopsy morphologic features that may predict a close (≤ 0.2 cm) or positive margin in the subsequent excision. Forty-nine consecutive paired specimens [core biopsies with a maximal diagnosis of DCIS, and their corresponding excisions, which included 20 and 29 specimens from mastectomies and breast conserving surgeries respectively] were evaluated in detail. In 5 (10%) of 49 cases, no residual carcinoma was found in the excision. In another 4 cases, the changes were diagnostic only of atypical ductal hyperplasia. There were 4 and 3 respective cases of invasive and microinvasive carcinoma out of the 49 excision specimens, for an overall invasion frequency of 14%. In 28 cases where a sentinel lymph node evaluation was performed, only 1 was found to be positive. Among the 40 cases with at least residual DCIS in the excision, there were 5 cases in which comedo-pattern DCIS was present in the excision but not in the core biopsy, attributed to the lower maximal nuclear grade in the biopsy proliferation in 4 cases and the absence of central necrosis in the 5th. For the other main histologic patterns, in 8 (20%) of 40 cases, there were more patterns identified in the core biopsy than in the corresponding excision. For the other 32 cases, 100%, 66%, 50%, 33% and 25% of the number of histologic patterns in the excisions were captured in 35%, 5%, 17.5%, 15% and 7.5% of the preceding core biopsies respectively. Therefore, the core biopsy reflected at least half of the non-comedo histologic patterns in 77.5% of cases. In 6(15%) of the 40 cases, the maximum nuclear grade of the excision (grade 3) was higher than that seen in the core biopsy (grade 2). Overall, however, the maximum nuclear grade in the excision was significantly predicted by maximum nuclear grade in the core biopsy (p = 0.028), with a Phi of 0.347, indicating a moderately strong association. At a size threshold of 2.7 cm, there was no significant association between lesional size and core biopsy features. Furthermore, the clear margin width of the cases with lesional size ≤ 2.7 cm (mean 0.69 cm) was not significantly different (p = 0.4) from the cases with lesional size > 2.7 cm (mean 0.56 cm). Finally, among a variety of core biopsy features that were evaluated, including maximum nuclear grade, necrosis, cancerization of lobules, number of tissue cores with DCIS, number of DCIS ducts per tissue core, total DCIS ducts, or comedo-pattern, only necrosis was significantly associated with a positive or close (≤ 0.2 cm) margin on multivariate analysis (Phi of 0.350). It is concluded that a significant change [to invasive disease (14%) or to no residual disease (10%)] is seen in approximately 24% of excisions that follow a core biopsy diagnosis of intermediate or high-grade DCIS. Core biopsy features are of limited value in predicting a close or positive margin in these lesions." @default.
• W2099724688 created "2016-06-24" @default.
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• W2099724688 date "2009-01-01" @default.
• W2099724688 modified "2023-09-26" @default.
• W2099724688 title "High and intermediate grade ductal carcinoma in-situ of the breast: a comparison of pathologic features in core biopsies and excisions and an evaluation of core biopsy features that may predict a close or positive margin in the excision" @default.
• W2099724688 cites W1561534109 @default.
• W2099724688 cites W1589510384 @default.
• W2099724688 cites W1592142216 @default.
• W2099724688 cites W1676259317 @default.
• W2099724688 cites W1744046449 @default.
• W2099724688 cites W1974739616 @default.
• W2099724688 cites W1992838105 @default.
• W2099724688 cites W1995969119 @default.
• W2099724688 cites W1999947134 @default.
• W2099724688 cites W2004218011 @default.
• W2099724688 cites W2006532743 @default.
• W2099724688 cites W2007455663 @default.
• W2099724688 cites W2007998248 @default.
• W2099724688 cites W2009413874 @default.
• W2099724688 cites W2010871781 @default.
• W2099724688 cites W2013306964 @default.
• W2099724688 cites W2024623089 @default.
• W2099724688 cites W2026745527 @default.
• W2099724688 cites W2028266208 @default.
• W2099724688 cites W2029798824 @default.
• W2099724688 cites W2034955502 @default.
• W2099724688 cites W2035176234 @default.
• W2099724688 cites W2035496236 @default.
• W2099724688 cites W2035689538 @default.
• W2099724688 cites W2038184054 @default.
• W2099724688 cites W2039980786 @default.
• W2099724688 cites W2042696772 @default.
• W2099724688 cites W2047046414 @default.
• W2099724688 cites W2048675427 @default.
• W2099724688 cites W2048897879 @default.
• W2099724688 cites W2049873393 @default.
• W2099724688 cites W2050818040 @default.
• W2099724688 cites W2052871830 @default.
• W2099724688 cites W2054587048 @default.
• W2099724688 cites W2056024228 @default.
• W2099724688 cites W2071906932 @default.
• W2099724688 cites W2072368010 @default.
• W2099724688 cites W2072887616 @default.
• W2099724688 cites W2085824155 @default.
• W2099724688 cites W2087800498 @default.
• W2099724688 cites W2089504583 @default.
• W2099724688 cites W2093233354 @default.
• W2099724688 cites W2095137807 @default.
• W2099724688 cites W2098755397 @default.
• W2099724688 cites W2098983979 @default.
• W2099724688 cites W2101210666 @default.
• W2099724688 cites W2126846866 @default.
• W2099724688 cites W2127171069 @default.
• W2099724688 cites W2129976756 @default.
• W2099724688 cites W2131195249 @default.
• W2099724688 cites W2133499228 @default.
• W2099724688 cites W2141059499 @default.
• W2099724688 cites W2144385581 @default.
• W2099724688 cites W2145470001 @default.
• W2099724688 cites W2150250432 @default.
• W2099724688 cites W2158468807 @default.
• W2099724688 cites W2162222454 @default.
• W2099724688 cites W2169211789 @default.
• W2099724688 cites W2315784891 @default.
• W2099724688 cites W2315967512 @default.
• W2099724688 cites W2331471618 @default.
• W2099724688 cites W2416265372 @default.
• W2099724688 cites W2425216640 @default.
• W2099724688 cites W90557341 @default.
• W2099724688 cites W98360954 @default.
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• W2099724688 doi "https://doi.org/10.1186/1746-1596-4-26" @default.
• W2099724688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2740842" @default.
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