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• W2099748940 abstract "ABSTRACT The prognosis for fulminant hepatic failure (FHF) still remains extremely poor with a high mortality and, therefore, better treatments are urgently needed. Syringin, a main active substance isolated from Eleutherococcus senticosus , has been reported to exhibit immunomodulatory and anti‐inflammatory properties. In this study, we investigated the effects and underlying mechanisms of syringin on lipopolysaccharide (LPS) and D‐galactosamine (D‐GalN)‐induced FHF in mice. Mice were administered syringin (10, 30 and 100 mg kg –1 , respectively) intraperitoneally (i.p) 30 min before LPS/D‐GalN then mortality and liver injury were evaluated subsequently. We found that syringin dose‐dependently attenuated LPS/D‐GalN‐induced FHF, as indicated by reduced mortality, inhibited aminotransferase and malondialdehyde (MDA) content, an increased glutathione (GSH) concentration and alleviated pathological liver injury. In addition, syringin inhibited LPS/D‐GalN‐induced hepatic caspase‐3 activation and hepatocellular apoptosis, myeloperoxidase (MPO) activity and intercellular adhesion molecule‐1 (ICAM‐1) expression, as well as hepatic tissues tumor necrosis factor‐alpha (TNF‐α) production and NF‐κB activation in a dose‐dependent manner. These experimental data indicate that syringin might alleviate the FHF induced by LPS/D‐GalN through inhibiting NF‐κB activation to reduce TNF‐α production. Copyright © 2013 John Wiley & Sons, Ltd." @default.
• W2099748940 created "2016-06-24" @default.
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• W2099748940 date "2013-04-26" @default.
• W2099748940 modified "2023-10-18" @default.
• W2099748940 title "Hepatoprotective effects of syringin on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice" @default.
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• W2099748940 doi "https://doi.org/10.1002/jat.2876" @default.
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