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- W2099761799 abstract "Abstract Gibberellic acid (GA 3 ) has been worldwide used in agriculture as a plant growth regulator. The purpose of this study is to assess the effects of GA 3 on the morphology and the thyroid hormone levels in adult rats and their suckling pups. Animals were given daily 200 ppm GA 3 in drinking water from the 14th day of pregnancy until day 14 after delivery. Compared with a control group, GA 3 ‐treated mothers and pups showed an increase in body and thyroid weights, a decrease in plasma FT 4 and FT 3 levels, which were more pronounced in pups than in their mothers. Thyroid iodine content was also decreased in pups. These biochemical modifications corresponded histologically; the majority of follicles had cubical epithelial cells, which surrounded empty vesicular cavities. Toxicity was objectified by a significant increase in plasma malondialdehyde, protein carbonyls, and advanced oxidation protein products levels in GA 3 ‐treated dams and their suckling pups; while, the activities of superoxide dismutase, catalase, and glutathione peroxidase were decreased in plasma of both dams and their pups. Moreover, a significant decline was observed in plasma glutathione, nonprotein thiols, and vitamin C levels. We conclude that GA 3 treatment affects thyroid function and plasma antioxidant status in adult rats and their progeny." @default.
- W2099761799 created "2016-06-24" @default.
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- W2099761799 date "2011-10-18" @default.
- W2099761799 modified "2023-10-18" @default.
- W2099761799 title "Oxidative stress and thyroid impairment after gibberellic acid treatment in pregnant and lactating rats and their offspring" @default.
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- W2099761799 doi "https://doi.org/10.1002/biof.178" @default.
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