FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099767408> ?p ?o ?g. }

• W2099767408 endingPage "704" @default.
• W2099767408 startingPage "694" @default.
• W2099767408 abstract "IL-10 exhibits anti-inflammatory effects on activated rodent mast cells (MC) in vitro and inhibits allergen-induced airway inflammation in vivo in murine models. The effects of IL-10 on the allergic activation of human MC are presently unknown.In light of the well-known heterogeneity of mast cell reactivity between animal species, one cannot readily predict the response of human MC to IL-10. Moreover, the impact of IL-10 on MC-derived proinflammatory mediators is still unknown. Thus, the objective of this study was to investigate the effects of IL-10 on the release of inflammatory mediators by IgE/anti-IgE-challenged human cord blood-derived mast cells (CBMC), used as an in vitro model of MC phenotypically similar to human lung MC.Highly purified human MC were obtained by a first step of long-term culture of cord blood mononuclear cells in the presence of human recombinant stem cell factor (rhSCF) and of human recombinant IL-6 (rhIL-6), followed by a second step of purification by depletion of contaminating cells with an immunomagneticThe cells were treated with human IgE, then challenged with anti-human IgE, in the presence or the absence of recombinant rhIL-10 used at various concentrations. Histamine, tumour necrosis factor-alpha (TNF-alpha), IL-5 and IL-8 were measured in the various supernatants collected at different times after the beginning of the challenge.IL-10 inhibited the release of TNF-alpha and of IL-8, but not of IL-5, by activated CBMC. Interestingly, IL-10 also inhibited the release of histamine by activated CBMC, contrasting with data reported for rodent MC.These findings suggest that IL-10 might have anti-inflammatory effects on IgE/anti-IgE-challenged human MC by inhibiting their release of TNF-alpha, IL-8 and histamine. These data provide new insights into the control of human mast cell activation and might lead to a better knowledge of the cellular mechanisms controlling allergic reactions." @default.
• W2099767408 created "2016-06-24" @default.
• W2099767408 creator A5012646710 @default.
• W2099767408 creator A5020169596 @default.
• W2099767408 creator A5040053640 @default.
• W2099767408 creator A5064340795 @default.
• W2099767408 creator A5065004424 @default.
• W2099767408 creator A5080703743 @default.
• W2099767408 date "2001-05-01" @default.
• W2099767408 modified "2023-10-18" @default.
• W2099767408 title "Inhibition of IgE-induced activation of human mast cells by IL-10" @default.
• W2099767408 cites W1492203305 @default.
• W2099767408 cites W1529226217 @default.
• W2099767408 cites W1529918408 @default.
• W2099767408 cites W1607649154 @default.
• W2099767408 cites W1705770238 @default.
• W2099767408 cites W1828661048 @default.
• W2099767408 cites W1916213760 @default.
• W2099767408 cites W1919784796 @default.
• W2099767408 cites W1938231026 @default.
• W2099767408 cites W1959914147 @default.
• W2099767408 cites W1963575320 @default.
• W2099767408 cites W1966449856 @default.
• W2099767408 cites W1979984134 @default.
• W2099767408 cites W1992239252 @default.
• W2099767408 cites W1998539607 @default.
• W2099767408 cites W2012194278 @default.
• W2099767408 cites W2016563876 @default.
• W2099767408 cites W2017014849 @default.
• W2099767408 cites W2017077682 @default.
• W2099767408 cites W2017718332 @default.
• W2099767408 cites W2019282811 @default.
• W2099767408 cites W2023719869 @default.
• W2099767408 cites W2028396701 @default.
• W2099767408 cites W2032173473 @default.
• W2099767408 cites W2033177777 @default.
• W2099767408 cites W2037899271 @default.
• W2099767408 cites W2040932113 @default.
• W2099767408 cites W2043524766 @default.
• W2099767408 cites W2048330059 @default.
• W2099767408 cites W2051307972 @default.
• W2099767408 cites W2051388205 @default.
• W2099767408 cites W2055380721 @default.
• W2099767408 cites W2060135531 @default.
• W2099767408 cites W2066352122 @default.
• W2099767408 cites W2066779636 @default.
• W2099767408 cites W2071471366 @default.
• W2099767408 cites W2084990572 @default.
• W2099767408 cites W2088260949 @default.
• W2099767408 cites W2092025680 @default.
• W2099767408 cites W2112802424 @default.
• W2099767408 cites W2124146654 @default.
• W2099767408 cites W2127842048 @default.
• W2099767408 cites W2138168133 @default.
• W2099767408 cites W2159881353 @default.
• W2099767408 cites W2161948102 @default.
• W2099767408 cites W216362062 @default.
• W2099767408 cites W2170248440 @default.
• W2099767408 cites W2185876434 @default.
• W2099767408 cites W256605437 @default.
• W2099767408 cites W4229688459 @default.
• W2099767408 cites W4255780862 @default.
• W2099767408 cites W4313335099 @default.
• W2099767408 cites W4313347690 @default.
• W2099767408 doi "https://doi.org/10.1046/j.1365-2222.2001.01069.x" @default.
• W2099767408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11422128" @default.
• W2099767408 hasPublicationYear "2001" @default.
• W2099767408 type Work @default.
• W2099767408 sameAs 2099767408 @default.
• W2099767408 citedByCount "165" @default.
• W2099767408 countsByYear W20997674082012 @default.
• W2099767408 countsByYear W20997674082013 @default.
• W2099767408 countsByYear W20997674082014 @default.
• W2099767408 countsByYear W20997674082015 @default.
• W2099767408 countsByYear W20997674082016 @default.
• W2099767408 countsByYear W20997674082017 @default.
• W2099767408 countsByYear W20997674082018 @default.
• W2099767408 countsByYear W20997674082019 @default.
• W2099767408 countsByYear W20997674082020 @default.
• W2099767408 countsByYear W20997674082021 @default.
• W2099767408 countsByYear W20997674082022 @default.
• W2099767408 countsByYear W20997674082023 @default.
• W2099767408 crossrefType "journal-article" @default.
• W2099767408 hasAuthorship W2099767408A5012646710 @default.
• W2099767408 hasAuthorship W2099767408A5020169596 @default.
• W2099767408 hasAuthorship W2099767408A5040053640 @default.
• W2099767408 hasAuthorship W2099767408A5064340795 @default.
• W2099767408 hasAuthorship W2099767408A5065004424 @default.
• W2099767408 hasAuthorship W2099767408A5080703743 @default.
• W2099767408 hasConcept C104317684 @default.
• W2099767408 hasConcept C1122143 @default.
• W2099767408 hasConcept C137061746 @default.
• W2099767408 hasConcept C141105273 @default.
• W2099767408 hasConcept C159654299 @default.
• W2099767408 hasConcept C164027704 @default.
• W2099767408 hasConcept C17991360 @default.
• W2099767408 hasConcept C185592680 @default.
• W2099767408 hasConcept C202751555 @default.

• next