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• W2099777002 abstract "The serotonin 5-HT(3) receptor native to rat hippocampal CA1 stratum radiatum interneurons is blocked by Ca(2+) ions in a dose- and voltage-dependent manner, which is reflected by a region of negative slope conductance in the I-V curve. The steep dependence on the extracellular Ca(2+) concentration suggests that the channel contains more than one binding site for Ca(2+). A three barrier-two site model, based on Eyring rate theory, was used to describe the I-V curves. When extra- and intracellular K(+) and Cs(+) were substituted with Na(+), the I-V curves were accurately fit by the model, unlike the I-V curves recorded under standard ionic conditions. This suggests that the K(+) and Cs(+) permeabilities are small compared with that of Na(+). The distribution of the energy barriers and binding sites for Ca(2+) and Na(+) showed that the binding sites are located at approximately the 13' and the -4' position in the ion channel. The model predicts that at large hyperpolarized membrane potentials (more negative than -120 mV), the fractional Ca(2+) current amounts to approximately 1% of the total ion current. However, at physiologically relevant membrane potentials, the fractional Ca(2+) current is smaller (<0.1%) and the relative Ca(2+) permeability (P(Ca)/P(Na)) is estimated to be 0.10 at -60 mV." @default.
• W2099777002 created "2016-06-24" @default.
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• W2099777002 date "2003-04-01" @default.
• W2099777002 modified "2023-10-16" @default.
• W2099777002 title "Ca²⁺ Ions Block and Permeate Serotonin 5-HT₃ Receptor Channels in Rat Hippocampal Interneurons" @default.
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• W2099777002 doi "https://doi.org/10.1152/jn.00948.2002" @default.
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