FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099777739> ?p ?o ?g. }

• W2099777739 abstract "Mexico City Metropolitan Area children chronically exposed to high concentrations of air pollutants exhibit an early brain imbalance in genes involved in oxidative stress, inflammation, innate and adaptive immune responses along with accumulation of misfolded proteins observed in the early stages of Alzheimer and Parkinson's diseases. A complex modulation of serum cytokines and chemokines influences children's brain structural and gray/white matter volumetric responses to air pollution. The search for biomarkers associating systemic and CNS inflammation to brain growth and cognitive deficits in the short term and neurodegeneration in the long-term is our principal aim. We explored and compared a profile of cytokines, chemokines (Multiplexing LASER Bead Technology) and Cellular prion protein (PrP(C)) in normal cerebro-spinal-fluid (CSF) of urban children with high vs. low air pollution exposures. PrP(C) and macrophage inhibitory factor (MIF) were also measured in serum. Samples from 139 children ages 11.91 ± 4.2 years were measured. Highly exposed children exhibited significant increases in CSF MIF (p = 0.002), IL6 (p = 0.006), IL1ra (p = 0.014), IL-2 (p = 0.04), and PrP(C) (p = 0.039) vs. controls. MIF serum concentrations were higher in exposed children (p = 0.009). Our results suggest CSF as a MIF, IL6, IL1Ra, IL-2, and PrP(C) compartment that can possibly differentiate air pollution exposures in children. MIF, a key neuro-immune mediator, is a potential biomarker bridge to identify children with CNS inflammation. Fine tuning of immune-to-brain communication is crucial to neural networks appropriate functioning, thus the short and long term effects of systemic inflammation and dysregulated neural immune responses are of deep concern for millions of exposed children. Defining the linkage and the health consequences of the brain / immune system interactions in the developing brain chronically exposed to air pollutants ought to be of pressing importance for public health." @default.
• W2099777739 created "2016-06-24" @default.
• W2099777739 creator A5003718052 @default.
• W2099777739 creator A5017464998 @default.
• W2099777739 creator A5019501082 @default.
• W2099777739 creator A5036064445 @default.
• W2099777739 creator A5046695508 @default.
• W2099777739 creator A5053865238 @default.
• W2099777739 creator A5063309068 @default.
• W2099777739 creator A5068837856 @default.
• W2099777739 creator A5072064474 @default.
• W2099777739 creator A5077961759 @default.
• W2099777739 creator A5091765639 @default.
• W2099777739 date "2013-01-01" @default.
• W2099777739 modified "2023-10-14" @default.
• W2099777739 title "Brain immune interactions and air pollution: macrophage inhibitory factor (MIF), prion cellular protein (PrPC), Interleukin-6 (IL-6), interleukin 1 receptor antagonist (IL-1Ra), and interleukin-2 (IL-2) in cerebrospinal fluid and MIF in serum differentiate urban children exposed to severe vs. low air pollution" @default.
• W2099777739 cites W140336411 @default.
• W2099777739 cites W1542215809 @default.
• W2099777739 cites W1543480580 @default.
• W2099777739 cites W1562902980 @default.
• W2099777739 cites W1569828475 @default.
• W2099777739 cites W1571725385 @default.
• W2099777739 cites W158846700 @default.
• W2099777739 cites W1608102072 @default.
• W2099777739 cites W163230262 @default.
• W2099777739 cites W1665321266 @default.
• W2099777739 cites W1964367858 @default.
• W2099777739 cites W1964390289 @default.
• W2099777739 cites W1965667994 @default.
• W2099777739 cites W1967800794 @default.
• W2099777739 cites W1968931382 @default.
• W2099777739 cites W1971768702 @default.
• W2099777739 cites W1973373696 @default.
• W2099777739 cites W1973922157 @default.
• W2099777739 cites W1975803474 @default.
• W2099777739 cites W1976118830 @default.
• W2099777739 cites W1979036899 @default.
• W2099777739 cites W1980506947 @default.
• W2099777739 cites W1981197262 @default.
• W2099777739 cites W1983052404 @default.
• W2099777739 cites W1983115003 @default.
• W2099777739 cites W1984620144 @default.
• W2099777739 cites W1987945174 @default.
• W2099777739 cites W1989036001 @default.
• W2099777739 cites W1990362540 @default.
• W2099777739 cites W1991134307 @default.
• W2099777739 cites W1991503866 @default.
• W2099777739 cites W1991785215 @default.
• W2099777739 cites W2000036908 @default.
• W2099777739 cites W2000481487 @default.
• W2099777739 cites W2000543953 @default.
• W2099777739 cites W2001525797 @default.
• W2099777739 cites W2003622777 @default.
• W2099777739 cites W2003804198 @default.
• W2099777739 cites W2008617310 @default.
• W2099777739 cites W2008788704 @default.
• W2099777739 cites W2008925119 @default.
• W2099777739 cites W2009755157 @default.
• W2099777739 cites W2010036720 @default.
• W2099777739 cites W2012162311 @default.
• W2099777739 cites W2012365123 @default.
• W2099777739 cites W2012610329 @default.
• W2099777739 cites W2014809568 @default.
• W2099777739 cites W2015940354 @default.
• W2099777739 cites W2017502139 @default.
• W2099777739 cites W2020604513 @default.
• W2099777739 cites W2020938916 @default.
• W2099777739 cites W2022392583 @default.
• W2099777739 cites W2024960053 @default.
• W2099777739 cites W2026352314 @default.
• W2099777739 cites W2029812468 @default.
• W2099777739 cites W2031447950 @default.
• W2099777739 cites W2031721046 @default.
• W2099777739 cites W2031910229 @default.
• W2099777739 cites W2034142305 @default.
• W2099777739 cites W2035656282 @default.
• W2099777739 cites W2037391150 @default.
• W2099777739 cites W2039054570 @default.
• W2099777739 cites W2040170948 @default.
• W2099777739 cites W2045792222 @default.
• W2099777739 cites W2047068620 @default.
• W2099777739 cites W2048360441 @default.
• W2099777739 cites W2049927826 @default.
• W2099777739 cites W2050725315 @default.
• W2099777739 cites W2051018963 @default.
• W2099777739 cites W2053341599 @default.
• W2099777739 cites W2055750901 @default.
• W2099777739 cites W2058664657 @default.
• W2099777739 cites W2060585119 @default.
• W2099777739 cites W2062444917 @default.
• W2099777739 cites W2062824264 @default.
• W2099777739 cites W2064127497 @default.
• W2099777739 cites W2066048879 @default.
• W2099777739 cites W2067022656 @default.
• W2099777739 cites W2067278652 @default.
• W2099777739 cites W2068602112 @default.
• W2099777739 cites W2069748884 @default.
• W2099777739 cites W2071530482 @default.
• W2099777739 cites W2071870096 @default.
• W2099777739 cites W2071956136 @default.

• next