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- W2099795802 abstract "Many core oscillator components of the circadian clock are nuclear localized but how the phase and rate of their entry contribute to clock function is unknown. TOC1/PRR1, a pseudoresponse regulator (PRR) protein, is a central element in one of the feedback loops of the Arabidopsis clock, but how it functions is unknown. Both TOC1 and a closely related protein, PRR5, are nuclear localized, expressed in the same phase, and shorten period when deficient, but their molecular relationship is unclear. Here, we find that both proteins interact in vitro and in vivo through their conserved N-termini. TOC1-PRR5 oligomerization enhances TOC1 nuclear accumulation two-fold, most likely through enhanced nuclear import. In addition, PRR5 recruits TOC1 to large subnuclear foci and promotes phosphorylation of the TOC1 N-terminus. Our results show that nuclear TOC1 is essential for normal clock function and reveal a mechanism to enhance phase-specific TOC1 nuclear accumulation. Interestingly, this process of regulated nuclear import is reminiscent of similar oligomeric pairings in animal clock systems (e.g. timeless/period and clock/cycle), suggesting evolutionary convergence of a conserved mechanism across kingdoms." @default.
- W2099795802 created "2016-06-24" @default.
- W2099795802 creator A5036866876 @default.
- W2099795802 creator A5037609463 @default.
- W2099795802 creator A5082427468 @default.
- W2099795802 date "2010-04-20" @default.
- W2099795802 modified "2023-10-01" @default.
- W2099795802 title "PRR5 regulates phosphorylation, nuclear import and subnuclear localization of TOC1 in the Arabidopsis circadian clock" @default.
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- W2099795802 doi "https://doi.org/10.1038/emboj.2010.76" @default.
- W2099795802 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2944058" @default.
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