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• W2099796728 abstract "Although simple cysts are easily identified using sonography, description and management of nonsimple cysts remains uncertain. This study evaluated whether the correlation coefficient differences between breast tissue and lesions, obtained from 2D breast elastography, could potentially distinguish nonsimple cysts from cancers and fibroadenomas. We hypothesized that correlation coefficients in cysts would be dramatically lower than surrounding tissue because noise, imaging artifacts, and particulate matter move randomly and decorrelate quickly under compression, compared with solid tissue. For this preliminary study, 18 breast lesions (7 nonsimple cysts, 4 cancers, and 7 fibroadenomas) underwent imaging with 2D elastography at 7.5 MHz through a TPX (a polymethyl pentene copolymer) 2.5 mm mammographic paddle. Breasts were compressed similar to mammographic positioning and then further compressed for elastography by 1 to 7%. Images were correlated using 2D phase-sensitive speckle tracking algorithms and displacement estimates were accumulated. Correlation coefficient means and standard deviations were measured in the lesion and adjacent tissue, and the differential correlation coefficient (DCC) was introduced as the difference between these values normalized to the correlation coefficient of adjacent tissue. Mean DCC values in nonsimple cysts were 24.2 ± 11.6%, 5.7 ± 6.3% for fibroadenomas, and 3.8 ± 2.9 % for cancers (p < 0.05). Some of the cysts appeared smaller in DCC images than gray-scale images. These encouraging results demonstrate that characterization of nonsimple breast cysts may be improved by using DCC values from 2D elastography, which could potentially change management options of these cysts from intervention to imaging follow-up. A dedicated clinical trial to fully assess the efficacy of this technique is recommended. (E-mail: [email protected] )" @default.
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• W2099796728 date "2008-01-01" @default.
• W2099796728 modified "2023-09-27" @default.
• W2099796728 title "Characterization of Cysts Using Differential Correlation Coefficient Values from Two Dimensional Breast Elastography: Preliminary Study" @default.
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• W2099796728 doi "https://doi.org/10.1016/j.ultrasmedbio.2007.07.003" @default.
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