FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099796906> ?p ?o ?g. }

• W2099796906 endingPage "491" @default.
• W2099796906 startingPage "486" @default.
• W2099796906 abstract "ABSTRACT Human lactoferrin (hLf), a glycoprotein released from neutrophil granules during inflammation, and the lipopolysaccharide (LPS)-binding protein (LBP), an acute-phase serum protein, are known to bind to the lipid A of LPS. The LPS-binding sites are located in the N-terminal regions of both proteins, at amino acid residues 28 to 34 of hLf and 91 to 108 of LBP. Both of these proteins modulate endotoxin activities, but they possess biologically antagonistic properties. In this study, we have investigated the competition between hLf and recombinant human LBP (rhLBP) for the binding of Escherichia coli 055:B5 LPS to the differentiated monocytic THP-1 cell line. Our studies revealed that hLf prevented the rhLBP-mediated binding of LPS to the CD14 receptor on cells. Maximal inhibition of LPS-cell interactions by hLf was raised when both hLf and rhLBP were simultaneously added to LPS or when hLf and LPS were mixed with cells 30 min prior to the incubation with rhLBP. However, when hLf was added 30 min after the interaction of rhLBP with LPS, the binding of the rhLPS-LBP complex to CD14 could not be reversed. These observations indicate that hLf competes with rhLBP for the LPS binding and therefore interferes with the interaction of LPS with CD14. Furthermore, experiments involving competitive binding of the rhLBP-LPS complex to cells with two recombinant mutated hLfs show that in addition to residues 28 to 34, another basic cluster which contains residues 1 to 5 of hLf competes for the binding to LPS. Basic sequences homologous to residues 28 to 34 of hLf were evidenced on LPS-binding proteins such as LBP, bactericidal/permeability-increasing protein, and Limulus anti-LPS factor." @default.
• W2099796906 created "2016-06-24" @default.
• W2099796906 creator A5003786309 @default.
• W2099796906 creator A5027290047 @default.
• W2099796906 creator A5029065498 @default.
• W2099796906 creator A5036332142 @default.
• W2099796906 creator A5037380925 @default.
• W2099796906 creator A5080563410 @default.
• W2099796906 creator A5082313294 @default.
• W2099796906 creator A5088770319 @default.
• W2099796906 date "1998-02-01" @default.
• W2099796906 modified "2023-10-17" @default.
• W2099796906 title "Lactoferrin Inhibits the Endotoxin Interaction with CD14 by Competition with the Lipopolysaccharide-Binding Protein" @default.
• W2099796906 cites W1252703846 @default.
• W2099796906 cites W128311047 @default.
• W2099796906 cites W14125072 @default.
• W2099796906 cites W1481001832 @default.
• W2099796906 cites W1512267378 @default.
• W2099796906 cites W1523183151 @default.
• W2099796906 cites W1524579535 @default.
• W2099796906 cites W1534164957 @default.
• W2099796906 cites W1546909952 @default.
• W2099796906 cites W1557652812 @default.
• W2099796906 cites W1568761178 @default.
• W2099796906 cites W1582984670 @default.
• W2099796906 cites W1622047218 @default.
• W2099796906 cites W1629538683 @default.
• W2099796906 cites W1802107548 @default.
• W2099796906 cites W184908838 @default.
• W2099796906 cites W1899762216 @default.
• W2099796906 cites W1903107546 @default.
• W2099796906 cites W1936475912 @default.
• W2099796906 cites W1965131749 @default.
• W2099796906 cites W1979131726 @default.
• W2099796906 cites W1989192012 @default.
• W2099796906 cites W1991236622 @default.
• W2099796906 cites W1997357193 @default.
• W2099796906 cites W1997857581 @default.
• W2099796906 cites W2004220277 @default.
• W2099796906 cites W2016900056 @default.
• W2099796906 cites W2018289835 @default.
• W2099796906 cites W2029157767 @default.
• W2099796906 cites W2036697040 @default.
• W2099796906 cites W2037464100 @default.
• W2099796906 cites W2043723908 @default.
• W2099796906 cites W2057108366 @default.
• W2099796906 cites W2064626913 @default.
• W2099796906 cites W2067338751 @default.
• W2099796906 cites W2072708040 @default.
• W2099796906 cites W2081453431 @default.
• W2099796906 cites W2088532306 @default.
• W2099796906 cites W2089746330 @default.
• W2099796906 cites W2098584990 @default.
• W2099796906 cites W2100503127 @default.
• W2099796906 cites W2100837269 @default.
• W2099796906 cites W2113828544 @default.
• W2099796906 cites W2120227455 @default.
• W2099796906 cites W2121453357 @default.
• W2099796906 cites W2123987062 @default.
• W2099796906 cites W2153560553 @default.
• W2099796906 cites W2163696121 @default.
• W2099796906 cites W2164008735 @default.
• W2099796906 cites W2164685578 @default.
• W2099796906 cites W2368227213 @default.
• W2099796906 cites W2417012319 @default.
• W2099796906 doi "https://doi.org/10.1128/iai.66.2.486-491.1998" @default.
• W2099796906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/107932" @default.
• W2099796906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9453600" @default.
• W2099796906 hasPublicationYear "1998" @default.
• W2099796906 type Work @default.
• W2099796906 sameAs 2099796906 @default.
• W2099796906 citedByCount "160" @default.
• W2099796906 countsByYear W20997969062012 @default.
• W2099796906 countsByYear W20997969062013 @default.
• W2099796906 countsByYear W20997969062014 @default.
• W2099796906 countsByYear W20997969062015 @default.
• W2099796906 countsByYear W20997969062016 @default.
• W2099796906 countsByYear W20997969062017 @default.
• W2099796906 countsByYear W20997969062018 @default.
• W2099796906 countsByYear W20997969062019 @default.
• W2099796906 countsByYear W20997969062020 @default.
• W2099796906 countsByYear W20997969062021 @default.
• W2099796906 countsByYear W20997969062022 @default.
• W2099796906 countsByYear W20997969062023 @default.
• W2099796906 crossrefType "journal-article" @default.
• W2099796906 hasAuthorship W2099796906A5003786309 @default.
• W2099796906 hasAuthorship W2099796906A5027290047 @default.
• W2099796906 hasAuthorship W2099796906A5029065498 @default.
• W2099796906 hasAuthorship W2099796906A5036332142 @default.
• W2099796906 hasAuthorship W2099796906A5037380925 @default.
• W2099796906 hasAuthorship W2099796906A5080563410 @default.
• W2099796906 hasAuthorship W2099796906A5082313294 @default.
• W2099796906 hasAuthorship W2099796906A5088770319 @default.
• W2099796906 hasBestOaLocation W20997969061 @default.
• W2099796906 hasConcept C104317684 @default.
• W2099796906 hasConcept C107824862 @default.
• W2099796906 hasConcept C108625454 @default.
• W2099796906 hasConcept C144464004 @default.

• next