Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099818893> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2099818893 endingPage "941" @default.
- W2099818893 startingPage "938" @default.
- W2099818893 abstract "Fluticasone propionate (FP) is a new corticosteroid that has been developed for the treatment of asthma. The compound has a very high receptor affinity, 18 times that of dexamethasone. After inhalation, FP is systemically available because of inhaled bioavailability. In healthy subjects this may lead to measurable systemic effects, such as cortisol reduction. A clinical study was conducted in 12 healthy volunteers to determine the systemic effects after inhaled administration of single 500-μg, 1,000-μg, and 2,000-μg doses of FP. Blood samples were collected over a 24-hour period after administration. Concentrations of FP and cortisol were measured in plasma by immunoassay. Cortisol reduction was chosen as the pharmacodynamic parameter. A novel linear release rate model was used to parameterize the cortisol data. The pharmacokinetics of FP were linear over the dose range studied. The cortisol release parameters were determined from baseline data (before drug administration). Based on these results, the E50 values for cortisol reduction were then determined for each dose of FP. The average E50 was 0.134 ng/mL for total FP concentrations and 0.013 ng/mL for unbound FP concentrations; these results were not dose dependent. These in vivo pharmacodynamic values measured in healthy subjects are in good agreement with the relatively high receptor affinity of FP." @default.
- W2099818893 created "2016-06-24" @default.
- W2099818893 creator A5013433944 @default.
- W2099818893 creator A5035083183 @default.
- W2099818893 creator A5040480138 @default.
- W2099818893 creator A5058057231 @default.
- W2099818893 creator A5077807315 @default.
- W2099818893 creator A5078485413 @default.
- W2099818893 creator A5078634243 @default.
- W2099818893 date "1996-10-01" @default.
- W2099818893 modified "2023-10-08" @default.
- W2099818893 title "Dynamic Modeling of Cortisol Reduction after Inhaled Administration of Fluticasone Propionate" @default.
- W2099818893 cites W2009241054 @default.
- W2099818893 cites W2030606718 @default.
- W2099818893 cites W2054954775 @default.
- W2099818893 cites W2062949406 @default.
- W2099818893 cites W2154889019 @default.
- W2099818893 doi "https://doi.org/10.1002/j.1552-4604.1996.tb04761.x" @default.
- W2099818893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8930781" @default.
- W2099818893 hasPublicationYear "1996" @default.
- W2099818893 type Work @default.
- W2099818893 sameAs 2099818893 @default.
- W2099818893 citedByCount "53" @default.
- W2099818893 countsByYear W20998188932012 @default.
- W2099818893 countsByYear W20998188932014 @default.
- W2099818893 countsByYear W20998188932015 @default.
- W2099818893 countsByYear W20998188932016 @default.
- W2099818893 countsByYear W20998188932019 @default.
- W2099818893 countsByYear W20998188932020 @default.
- W2099818893 countsByYear W20998188932023 @default.
- W2099818893 crossrefType "journal-article" @default.
- W2099818893 hasAuthorship W2099818893A5013433944 @default.
- W2099818893 hasAuthorship W2099818893A5035083183 @default.
- W2099818893 hasAuthorship W2099818893A5040480138 @default.
- W2099818893 hasAuthorship W2099818893A5058057231 @default.
- W2099818893 hasAuthorship W2099818893A5077807315 @default.
- W2099818893 hasAuthorship W2099818893A5078485413 @default.
- W2099818893 hasAuthorship W2099818893A5078634243 @default.
- W2099818893 hasConcept C111113717 @default.
- W2099818893 hasConcept C112705442 @default.
- W2099818893 hasConcept C126322002 @default.
- W2099818893 hasConcept C134018914 @default.
- W2099818893 hasConcept C181389837 @default.
- W2099818893 hasConcept C185592680 @default.
- W2099818893 hasConcept C2776042228 @default.
- W2099818893 hasConcept C2776804153 @default.
- W2099818893 hasConcept C2776954882 @default.
- W2099818893 hasConcept C2778709874 @default.
- W2099818893 hasConcept C2779028295 @default.
- W2099818893 hasConcept C2780401358 @default.
- W2099818893 hasConcept C2780841215 @default.
- W2099818893 hasConcept C2781212218 @default.
- W2099818893 hasConcept C42219234 @default.
- W2099818893 hasConcept C59493245 @default.
- W2099818893 hasConcept C71924100 @default.
- W2099818893 hasConcept C98274493 @default.
- W2099818893 hasConceptScore W2099818893C111113717 @default.
- W2099818893 hasConceptScore W2099818893C112705442 @default.
- W2099818893 hasConceptScore W2099818893C126322002 @default.
- W2099818893 hasConceptScore W2099818893C134018914 @default.
- W2099818893 hasConceptScore W2099818893C181389837 @default.
- W2099818893 hasConceptScore W2099818893C185592680 @default.
- W2099818893 hasConceptScore W2099818893C2776042228 @default.
- W2099818893 hasConceptScore W2099818893C2776804153 @default.
- W2099818893 hasConceptScore W2099818893C2776954882 @default.
- W2099818893 hasConceptScore W2099818893C2778709874 @default.
- W2099818893 hasConceptScore W2099818893C2779028295 @default.
- W2099818893 hasConceptScore W2099818893C2780401358 @default.
- W2099818893 hasConceptScore W2099818893C2780841215 @default.
- W2099818893 hasConceptScore W2099818893C2781212218 @default.
- W2099818893 hasConceptScore W2099818893C42219234 @default.
- W2099818893 hasConceptScore W2099818893C59493245 @default.
- W2099818893 hasConceptScore W2099818893C71924100 @default.
- W2099818893 hasConceptScore W2099818893C98274493 @default.
- W2099818893 hasIssue "10" @default.
- W2099818893 hasLocation W20998188931 @default.
- W2099818893 hasLocation W20998188932 @default.
- W2099818893 hasOpenAccess W2099818893 @default.
- W2099818893 hasPrimaryLocation W20998188931 @default.
- W2099818893 hasRelatedWork W1975221239 @default.
- W2099818893 hasRelatedWork W1992988294 @default.
- W2099818893 hasRelatedWork W2020812663 @default.
- W2099818893 hasRelatedWork W2030829101 @default.
- W2099818893 hasRelatedWork W2040008754 @default.
- W2099818893 hasRelatedWork W2055935555 @default.
- W2099818893 hasRelatedWork W2160477136 @default.
- W2099818893 hasRelatedWork W2343833591 @default.
- W2099818893 hasRelatedWork W3030704863 @default.
- W2099818893 hasRelatedWork W4231997767 @default.
- W2099818893 hasVolume "36" @default.
- W2099818893 isParatext "false" @default.
- W2099818893 isRetracted "false" @default.
- W2099818893 magId "2099818893" @default.
- W2099818893 workType "article" @default.