Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099819614> ?p ?o ?g. }
- W2099819614 endingPage "37" @default.
- W2099819614 startingPage "29" @default.
- W2099819614 abstract "The profibrogenic role of endothelin-1 (ET-1) and angiotensin-II (AT-II) in renal fibrosis remains disputed. We therefore studied the effect of ET-1 and AT-II on rat mesangial cells (CRL-2573), the major source of extracellular matrix proteins in the kidney. ET-1 stimulated DNA synthesis assessed by BrdU uptake in microtiter tetrazolium assay in a dose dependent manner, but AT-II did not. Proliferation of the mesangial cells by ET-1 was suppressed by 15% with BQ123, an endothelin receptor A antagonist, which suggested a significant role of the endothelin receptor A on growth stimulation. In the mesangial cells, ET-1 increased the mRNA expressions of procollagen α1 (I), transforming growth factor-β1, connective tissue growth factor, tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-13 in dose dependent manners, whereas AT-II had exerted no effect on the expression of these mRNAs. These data suggested that ET-1 might be involved in renal fibrosis through the mesangial cell proliferation and/or the increase in fibrogenic cytokines." @default.
- W2099819614 created "2016-06-24" @default.
- W2099819614 creator A5076037810 @default.
- W2099819614 date "2006-03-01" @default.
- W2099819614 modified "2023-09-28" @default.
- W2099819614 title "Effects of Endothelin-1 and Angiotensin-II on Extracellular Matrix Metabolism in a Rat Mesangial Cell Line, CRL-2573" @default.
- W2099819614 cites W2007616702 @default.
- W2099819614 cites W2035391762 @default.
- W2099819614 cites W2044265857 @default.
- W2099819614 cites W2049834465 @default.
- W2099819614 cites W2057336465 @default.
- W2099819614 cites W2069377309 @default.
- W2099819614 cites W2074636215 @default.
- W2099819614 cites W2076584321 @default.
- W2099819614 cites W2076804216 @default.
- W2099819614 cites W2093248070 @default.
- W2099819614 cites W2097524970 @default.
- W2099819614 cites W2101476601 @default.
- W2099819614 cites W2119572224 @default.
- W2099819614 cites W2124579702 @default.
- W2099819614 cites W2135966823 @default.
- W2099819614 cites W2138120299 @default.
- W2099819614 cites W2140814998 @default.
- W2099819614 cites W2141742095 @default.
- W2099819614 cites W2144673000 @default.
- W2099819614 cites W2162668748 @default.
- W2099819614 cites W2162804111 @default.
- W2099819614 cites W2334269819 @default.
- W2099819614 cites W2406192782 @default.
- W2099819614 hasPublicationYear "2006" @default.
- W2099819614 type Work @default.
- W2099819614 sameAs 2099819614 @default.
- W2099819614 citedByCount "0" @default.
- W2099819614 crossrefType "journal-article" @default.
- W2099819614 hasAuthorship W2099819614A5076037810 @default.
- W2099819614 hasConcept C109523444 @default.
- W2099819614 hasConcept C118131993 @default.
- W2099819614 hasConcept C126322002 @default.
- W2099819614 hasConcept C134018914 @default.
- W2099819614 hasConcept C144980905 @default.
- W2099819614 hasConcept C149601957 @default.
- W2099819614 hasConcept C170493617 @default.
- W2099819614 hasConcept C185592680 @default.
- W2099819614 hasConcept C189165786 @default.
- W2099819614 hasConcept C2775960820 @default.
- W2099819614 hasConcept C2779131090 @default.
- W2099819614 hasConcept C2780091579 @default.
- W2099819614 hasConcept C2780559512 @default.
- W2099819614 hasConcept C2908929049 @default.
- W2099819614 hasConcept C55493867 @default.
- W2099819614 hasConcept C62112901 @default.
- W2099819614 hasConcept C71924100 @default.
- W2099819614 hasConcept C86803240 @default.
- W2099819614 hasConcept C95444343 @default.
- W2099819614 hasConceptScore W2099819614C109523444 @default.
- W2099819614 hasConceptScore W2099819614C118131993 @default.
- W2099819614 hasConceptScore W2099819614C126322002 @default.
- W2099819614 hasConceptScore W2099819614C134018914 @default.
- W2099819614 hasConceptScore W2099819614C144980905 @default.
- W2099819614 hasConceptScore W2099819614C149601957 @default.
- W2099819614 hasConceptScore W2099819614C170493617 @default.
- W2099819614 hasConceptScore W2099819614C185592680 @default.
- W2099819614 hasConceptScore W2099819614C189165786 @default.
- W2099819614 hasConceptScore W2099819614C2775960820 @default.
- W2099819614 hasConceptScore W2099819614C2779131090 @default.
- W2099819614 hasConceptScore W2099819614C2780091579 @default.
- W2099819614 hasConceptScore W2099819614C2780559512 @default.
- W2099819614 hasConceptScore W2099819614C2908929049 @default.
- W2099819614 hasConceptScore W2099819614C55493867 @default.
- W2099819614 hasConceptScore W2099819614C62112901 @default.
- W2099819614 hasConceptScore W2099819614C71924100 @default.
- W2099819614 hasConceptScore W2099819614C86803240 @default.
- W2099819614 hasConceptScore W2099819614C95444343 @default.
- W2099819614 hasIssue "1" @default.
- W2099819614 hasLocation W20998196141 @default.
- W2099819614 hasOpenAccess W2099819614 @default.
- W2099819614 hasPrimaryLocation W20998196141 @default.
- W2099819614 hasRelatedWork W1964199332 @default.
- W2099819614 hasRelatedWork W1968675109 @default.
- W2099819614 hasRelatedWork W1978799672 @default.
- W2099819614 hasRelatedWork W1984261234 @default.
- W2099819614 hasRelatedWork W1987316872 @default.
- W2099819614 hasRelatedWork W1996560304 @default.
- W2099819614 hasRelatedWork W1997784247 @default.
- W2099819614 hasRelatedWork W2022319844 @default.
- W2099819614 hasRelatedWork W2027299913 @default.
- W2099819614 hasRelatedWork W2072670533 @default.
- W2099819614 hasRelatedWork W2072922478 @default.
- W2099819614 hasRelatedWork W2079016720 @default.
- W2099819614 hasRelatedWork W2138120299 @default.
- W2099819614 hasRelatedWork W2139369656 @default.
- W2099819614 hasRelatedWork W2158439879 @default.
- W2099819614 hasRelatedWork W2205247839 @default.
- W2099819614 hasRelatedWork W2330207153 @default.
- W2099819614 hasRelatedWork W235083404 @default.
- W2099819614 hasRelatedWork W2419165894 @default.
- W2099819614 hasRelatedWork W3145025514 @default.
- W2099819614 hasVolume "49" @default.