Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099831002> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2099831002 endingPage "66a" @default.
- W2099831002 startingPage "66a" @default.
- W2099831002 abstract "Nucleosome, consisting of a histone octamer with DNA wrapping around it, is the basic structural unit of the chromatin structure. It has been known that nucleosome positions are closely associated with the regulations of transcription, DNA replication, repair and recombination. How does the nucleosome dynamically change the position according to the states of the cell ?To understand the mechanism, we carried out molecular dynamics simulation to obtain free energy profiles for the position changes. We forcefully changed the relative position between DNA and a histone core with an adaptively biasing force method and obtained the free energy profile as a function of the relative rotational angle. The energy profiles show that the position change spontaneously occurs at some angles, while it costs about 10 to 15 kcal/mol to pass through the several angle regions where the strong electrostatic interactions exit between DNA phosphate atoms and histone tail atoms. Our result suggests that some factors such as remodelers are essential to pass through these energy barriers." @default.
- W2099831002 created "2016-06-24" @default.
- W2099831002 creator A5053952899 @default.
- W2099831002 creator A5078450140 @default.
- W2099831002 creator A5080123389 @default.
- W2099831002 date "2011-02-01" @default.
- W2099831002 modified "2023-10-18" @default.
- W2099831002 title "Free Energy Profiles for Nucleosome Position Changes" @default.
- W2099831002 doi "https://doi.org/10.1016/j.bpj.2010.12.561" @default.
- W2099831002 hasPublicationYear "2011" @default.
- W2099831002 type Work @default.
- W2099831002 sameAs 2099831002 @default.
- W2099831002 citedByCount "0" @default.
- W2099831002 crossrefType "journal-article" @default.
- W2099831002 hasAuthorship W2099831002A5053952899 @default.
- W2099831002 hasAuthorship W2099831002A5078450140 @default.
- W2099831002 hasAuthorship W2099831002A5080123389 @default.
- W2099831002 hasBestOaLocation W20998310021 @default.
- W2099831002 hasConcept C10138342 @default.
- W2099831002 hasConcept C121332964 @default.
- W2099831002 hasConcept C12554922 @default.
- W2099831002 hasConcept C144133560 @default.
- W2099831002 hasConcept C185592680 @default.
- W2099831002 hasConcept C186370098 @default.
- W2099831002 hasConcept C198082294 @default.
- W2099831002 hasConcept C54355233 @default.
- W2099831002 hasConcept C552990157 @default.
- W2099831002 hasConcept C62520636 @default.
- W2099831002 hasConcept C64927066 @default.
- W2099831002 hasConcept C84772758 @default.
- W2099831002 hasConcept C86803240 @default.
- W2099831002 hasConceptScore W2099831002C10138342 @default.
- W2099831002 hasConceptScore W2099831002C121332964 @default.
- W2099831002 hasConceptScore W2099831002C12554922 @default.
- W2099831002 hasConceptScore W2099831002C144133560 @default.
- W2099831002 hasConceptScore W2099831002C185592680 @default.
- W2099831002 hasConceptScore W2099831002C186370098 @default.
- W2099831002 hasConceptScore W2099831002C198082294 @default.
- W2099831002 hasConceptScore W2099831002C54355233 @default.
- W2099831002 hasConceptScore W2099831002C552990157 @default.
- W2099831002 hasConceptScore W2099831002C62520636 @default.
- W2099831002 hasConceptScore W2099831002C64927066 @default.
- W2099831002 hasConceptScore W2099831002C84772758 @default.
- W2099831002 hasConceptScore W2099831002C86803240 @default.
- W2099831002 hasIssue "3" @default.
- W2099831002 hasLocation W20998310021 @default.
- W2099831002 hasOpenAccess W2099831002 @default.
- W2099831002 hasPrimaryLocation W20998310021 @default.
- W2099831002 hasRelatedWork W2009702999 @default.
- W2099831002 hasRelatedWork W2010982418 @default.
- W2099831002 hasRelatedWork W2062514148 @default.
- W2099831002 hasRelatedWork W2138101627 @default.
- W2099831002 hasRelatedWork W2411795946 @default.
- W2099831002 hasRelatedWork W2473118655 @default.
- W2099831002 hasRelatedWork W2911205078 @default.
- W2099831002 hasRelatedWork W2950303753 @default.
- W2099831002 hasRelatedWork W2953020704 @default.
- W2099831002 hasRelatedWork W4296162192 @default.
- W2099831002 hasVolume "100" @default.
- W2099831002 isParatext "false" @default.
- W2099831002 isRetracted "false" @default.
- W2099831002 magId "2099831002" @default.
- W2099831002 workType "article" @default.