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- W2099842997 abstract "In order to obtain a reproducible experimental model of osteoarthritis a method of immobilizing the rabbit's knee in extension by means of plastic splint was developed. The right knees of the rabbits were immobilized for periods varying from 4 days to 24 weeks. With the left knees as controls the knees were studied in a variety of ways among these being radiography (126 rabbits), histological sections stained with Alcian Blue (88 rabbits), analysis of 35S-sulphate uptake (22 rabbits) and 35S-autoradiography (6 rabbits). In 27 rabbits the regaining of mobility after immobilization was studied. After 5-6 weeks of immobilization most of the knees showed moderate or severe changes including loss of articular cartlilage and osteophyte formation. Immobilization of the rabbit's knee by this method provokes a fairly easily reproducible type of degenerative joint disease showing similarities to advanced osteoarthritis as seen in humans." @default.
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- W2099842997 date "1979-01-01" @default.
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- W2099842997 title "Osteoarthritis of the Knee in the Rabbit Produced by Immobilization::<i>Attempts to Achieve a Reproducible Model for Studies on Pathogenesis and Therapy</i>" @default.
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- W2099842997 doi "https://doi.org/10.3109/17453677909024083" @default.
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