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- W2099843220 abstract "PROBLEM: We have previously demonstrated that human serum can suppress the proliferative response in autologous mixed lymphocyte reaction (AMLR) in which phytohemagglutinin (PHA)‐activated T lymphoblasts act as stimulators (T‐T PHA AMLR). The aim of the present work was to determine whether pregnancy serum (PS) possesses an inhibitory capacity similar or different in magnitude. METHODS: Sixteen PS were added to T‐T PHA AMLR cultures and the proliferative response was compared with that in the presence of human serum. The effect of PS on the IL‐2 dependent proliferation of PHA‐activated T Lymphoblasts was examined as well. RESULTS: PS induced a significantly more pronounced suppression of T‐T PHA AMLR than human serum ( P < 0.05). One PS tested was not inhibitory but rather stimulatory. This PS was obtained from a woman who subsequently had IUGR. The inhibition is related to the existence of a serum inhibitory factor and not to the lack of a serum supporting factor. PS inhibited not only T‐T PHA AMLR of the same woman but also T‐T PHA AMLR of other individuals as well, implying that the inhibitor is a non‐MHC restricted factor. IL‐2 dependent cell proliferation was not inhibited by PS, implying that the inhibitor detected in T‐T PHA AMLR is not a general cell proliferation inhibitor. CONCLUSIONS: These results suggest that a non‐MHC restricted inhibitory factor present in PS may play an important biological role in regulating local immune responses in the fetal‐placental unit mediated by autoreactive T cells restricted to autologous activated T lymphocytes." @default.
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- W2099843220 date "1996-02-01" @default.
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- W2099843220 title "Human Pregnancy Serum Suppresses the Proliferative Response of Lymphocytes to Autologous PHA-Activated T Lymphoblasts" @default.
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- W2099843220 doi "https://doi.org/10.1111/j.1600-0897.1996.tb00009.x" @default.
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