FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099843722> ?p ?o ?g. }

• W2099843722 endingPage "982" @default.
• W2099843722 startingPage "972" @default.
• W2099843722 abstract "The response to pegylated interferon (pegIFN) plus ribavirin (RBV) as treatment of chronic hepatitis C virus (HCV) infection is lower in HIV-coinfected than in HCV-monoinfected patients and could be due to suboptimal RBV dosing and/or insufficient duration of therapy in prior trials. In a prospective, multicenter, open, comparative trial, HCV/HIV-coinfected patients received pegIFN plus weight-based RBV for 48 or 72 weeks (HCV genotypes 1 and 4) and 24 or 48 weeks (HCV genotypes 2 and 3). Use of didanosine was not allowed. Out of 389 patients included in the trial, 61% were infected by HCV-1/4 and 67% had serum HCV-RNA >500,000 IU/ml. Sustained virological response (SVR) was achieved by 49.6%, significantly higher in HCV-2/3 than HCV-1/4 (72.4% vs. 35%; p < 0.0001). A high drop-out rate in the longer treatment arms precluded obtaining definitive conclusions about the efficacy of prolonging therapy. Premature treatment discontinuations due to serious adverse events occurred in 8.2%. Infection with HCV-2/3, lower baseline HCV-RNA, and negative HCV-RNA at week 12 were all independent predictors of SVR in the multivariate analysis. The use of RBV 1000-1200 mg/day plus pegIFN is relatively safe and provides SVR in nearly half of coinfected patients, twice as high in HCV-2/3 than HCV-1/4." @default.
• W2099843722 created "2016-06-24" @default.
• W2099843722 creator A5003487355 @default.
• W2099843722 creator A5003553956 @default.
• W2099843722 creator A5009751300 @default.
• W2099843722 creator A5015434274 @default.
• W2099843722 creator A5019841865 @default.
• W2099843722 creator A5025958254 @default.
• W2099843722 creator A5027520171 @default.
• W2099843722 creator A5028478010 @default.
• W2099843722 creator A5030580762 @default.
• W2099843722 creator A5042618056 @default.
• W2099843722 creator A5049839619 @default.
• W2099843722 creator A5051816129 @default.
• W2099843722 creator A5060134820 @default.
• W2099843722 creator A5066121827 @default.
• W2099843722 creator A5075118902 @default.
• W2099843722 creator A5083352060 @default.
• W2099843722 creator A5083888711 @default.
• W2099843722 creator A5084131412 @default.
• W2099843722 creator A5087702556 @default.
• W2099843722 date "2007-08-01" @default.
• W2099843722 modified "2023-10-14" @default.
• W2099843722 title "Role of Weight-Based Ribavirin Dosing and Extended Duration of Therapy in Chronic Hepatitis C in HIV-Infected Patients: The PRESCO Trial" @default.
• W2099843722 cites W1967080996 @default.
• W2099843722 cites W1970053808 @default.
• W2099843722 cites W1978252126 @default.
• W2099843722 cites W1986283951 @default.
• W2099843722 cites W1987268569 @default.
• W2099843722 cites W1992239172 @default.
• W2099843722 cites W1993484328 @default.
• W2099843722 cites W1996434966 @default.
• W2099843722 cites W2000819506 @default.
• W2099843722 cites W2004602615 @default.
• W2099843722 cites W2005933189 @default.
• W2099843722 cites W2007062588 @default.
• W2099843722 cites W2007209701 @default.
• W2099843722 cites W2007921510 @default.
• W2099843722 cites W2008738660 @default.
• W2099843722 cites W2018446644 @default.
• W2099843722 cites W2019816650 @default.
• W2099843722 cites W2024049300 @default.
• W2099843722 cites W2026945575 @default.
• W2099843722 cites W2027545702 @default.
• W2099843722 cites W2032412852 @default.
• W2099843722 cites W2033929071 @default.
• W2099843722 cites W2045819740 @default.
• W2099843722 cites W2061294380 @default.
• W2099843722 cites W2061501244 @default.
• W2099843722 cites W2063859957 @default.
• W2099843722 cites W2065534484 @default.
• W2099843722 cites W2071586067 @default.
• W2099843722 cites W2094883696 @default.
• W2099843722 cites W2102371310 @default.
• W2099843722 cites W2103529803 @default.
• W2099843722 cites W2111790487 @default.
• W2099843722 cites W2112876622 @default.
• W2099843722 cites W2113869422 @default.
• W2099843722 cites W2121595515 @default.
• W2099843722 cites W2122764811 @default.
• W2099843722 cites W2127685726 @default.
• W2099843722 cites W2131109099 @default.
• W2099843722 cites W2142746239 @default.
• W2099843722 cites W2151020178 @default.
• W2099843722 cites W2153921667 @default.
• W2099843722 cites W2160997908 @default.
• W2099843722 cites W2171689172 @default.
• W2099843722 cites W2404044846 @default.
• W2099843722 cites W30491805 @default.
• W2099843722 doi "https://doi.org/10.1089/aid.2007.0011" @default.
• W2099843722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17725413" @default.
• W2099843722 hasPublicationYear "2007" @default.
• W2099843722 type Work @default.
• W2099843722 sameAs 2099843722 @default.
• W2099843722 citedByCount "185" @default.
• W2099843722 countsByYear W20998437222012 @default.
• W2099843722 countsByYear W20998437222013 @default.
• W2099843722 countsByYear W20998437222014 @default.
• W2099843722 countsByYear W20998437222015 @default.
• W2099843722 countsByYear W20998437222016 @default.
• W2099843722 countsByYear W20998437222018 @default.
• W2099843722 countsByYear W20998437222020 @default.
• W2099843722 crossrefType "journal-article" @default.
• W2099843722 hasAuthorship W2099843722A5003487355 @default.
• W2099843722 hasAuthorship W2099843722A5003553956 @default.
• W2099843722 hasAuthorship W2099843722A5009751300 @default.
• W2099843722 hasAuthorship W2099843722A5015434274 @default.
• W2099843722 hasAuthorship W2099843722A5019841865 @default.
• W2099843722 hasAuthorship W2099843722A5025958254 @default.
• W2099843722 hasAuthorship W2099843722A5027520171 @default.
• W2099843722 hasAuthorship W2099843722A5028478010 @default.
• W2099843722 hasAuthorship W2099843722A5030580762 @default.
• W2099843722 hasAuthorship W2099843722A5042618056 @default.
• W2099843722 hasAuthorship W2099843722A5049839619 @default.
• W2099843722 hasAuthorship W2099843722A5051816129 @default.
• W2099843722 hasAuthorship W2099843722A5060134820 @default.
• W2099843722 hasAuthorship W2099843722A5066121827 @default.
• W2099843722 hasAuthorship W2099843722A5075118902 @default.

• next