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- W2099844546 abstract "Psychiatric toxicity to tnicycic antidepressants may be an underrecognized adverse effect of treatment with tricyclics, possibly occurring in between 5 and 15 percent of patients. Such toxicity is probably mediated by a central antimuscarinic action of the tricyclics and is associated with elevated plasma tricyclic levels, age, polypharmacy, and perhaps underlying cholinergic defects in susceptible individuals. Once tricyclic-induced toxicity is recognized, the treatment consists of discontinuing the tricyclic and providing supportive care as necessary. Many cases of tricyclic-induced toxicity may be preventable through close attention to the mental status examination and judicious monitoring of plasma tricyclic levels during treatment." @default.
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- W2099844546 date "1990-01-01" @default.
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- W2099844546 title "Psychiatric Side Effects of Tricyclic Antidepressants" @default.
- W2099844546 cites W2004529130 @default.
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- W2099844546 doi "https://doi.org/10.1176/ps.41.1.84" @default.
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