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- W2099844556 abstract "Clerocidin, a diterpenoid natural product, has been shown in vitro to inhibit DNA religation following cleavage by topoisomerase II. Herein, we characterize the efficacy and specificity of clerocidin in HeLa cells. Our results suggest that clerocidin recognizes topoisomerase II as its main intracellular target and binds to this enzyme prior to formation of the 'cleavable complex' with DNA. These pharmacological features attest to the promising chemotherapeutic potential of this natural product." @default.
- W2099844556 created "2016-06-24" @default.
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- W2099844556 date "2001-06-01" @default.
- W2099844556 modified "2023-09-27" @default.
- W2099844556 title "Investigation of the biological mode of action of clerocidin using whole cell assays" @default.
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- W2099844556 doi "https://doi.org/10.1016/s0968-0896(01)00051-7" @default.
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