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• W2099844895 abstract "Direct fusion between Jurkat cell and a liposome modified with poly(ethylene oxide)-bearing lipid (PEO-lipid) was examined using diphtheria toxin fragment A (DTA) as the probe. Only the DTA-loaded liposome modified with PEO-lipid(n = 32) (n is the number of ethylene oxide units) exerted significant cytotoxicity against Jurkat cells, while liposomes lacking either the PEO-lipid or DTA did not. Liposomes modified by the PEO-lipid with shorter PEO chain(n = 5 or 15) did not show any cytotoxicity, irrespective of their DTA-loading. The cytotoxicity was observed even in the presence of cytochalasin B, an inhibitor of endocytosis. Judging from these results, we concluded that the PEO-lipid(n = 32)-modified liposome directly fused with plasma membrane of Jurkat cell." @default.
• W2099844895 created "2016-06-24" @default.
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• W2099844895 date "1996-12-01" @default.
• W2099844895 modified "2023-09-25" @default.
• W2099844895 title "Fusion between Jurkat cell and PEO-lipid modified liposome" @default.
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• W2099844895 doi "https://doi.org/10.1016/s0005-2736(96)00159-9" @default.
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