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- W2099860198 abstract "The characteristics of implantation stage endometrium following a single-dose, early luteal phase application of mifeprlstone (RU486) in proven conception cycles has been examined in the rhesus monkey in an attempt to understand the physiological basis of the anti-implantation activity of the drug. Endometrial samples were collected from monkeys subjected to vehicle (group 1, n±14) and RU486 (2 mg/kg body weight; group 2, n±12) on day 2 after the presumed day of ovulation of successfully mated cycles. The average diameter of glands (P <0.05), number of vacuolated cells (P <0.01), number of supranuclear vacuolated cells (P <0.05) in glandular epithelium and amount of glandular secretion (P <0.05) were significantly lower in RU486-treated endometrium compared with control tissue samples. Additionally, 18% of glandular epithelial cells showed apoptotic and degenerative features in RU486-treated tissue samples. These data, together with the observed significant decreases in precipitate area (P <0.02) and in the optical absorbance of alkaline phosphatase reaction end-product (P <0.05), confirm that retardation in glandular differentiation in the upper functionalls is a likely target of antiprogestin action in implantation stage endometrium. An increased frequency of mitosis in stromal cells (P <0.05) and a greater degree of extravasation (P <0.05) were also observed after RU486 exposure. Despite an apparent indication of constriction and regression in few RU486-exposed endometria compared with controls, morphometric analyses did not show any changes in capillary structure. Whether endometrial vasculature in progesterone-exposed uterus is a target of antiprogeslin action during the pen-implantation stage remains to be determined. Further studies are required to explain the observed increase (P <0.02) in the area of precipitate of von Willebrand (vW) factor with no change in vW factor-positive vessels, and the apparent increase in collagen IV immunostain in subepitheliai and perivascular basement membrane in Implantation stage endometrium after early luteal phase RU486 treatment in monkeys." @default.
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- W2099860198 title "Implantation and early pregnancy: Effect of single-dose, early luteal phase administration of mifepristone (RU486) on implantation stage endometrium in the rhesus monkey" @default.
- W2099860198 doi "https://doi.org/10.1093/oxfordjournals.humrep.a019538" @default.
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