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- W2099872783 abstract "Abstract This review summarizes the current status of knowledge on asymmetric iridium-catalyzed direct hydrogenations of acyclic and cyclic imines. An overview of the most interesting catalysts with respect to selectivity, activity and substrate scope is given, including a discussion of the effects of different reaction conditions on the enantioselectivity of imine reduction. A detailed analysis of proposed imine hydrogenation mechanisms is presented, revealing that a significant number of recent proposals suggest outer sphere mechanisms, implying that the substrate does not bind to the metal centre during the hydrogenation reaction. An intriguing question is how a high enantioselectivity can be achieved in such systems. Generally, the factors governing the stereocontrol of iridium-catalyzed direct imine hydrogenation are little studied. The mechanistic proposals that have been put forward to explain the enantiodiscrimination of selected complexes are reviewed here, showing that the stereocontrol appears to be governed by weak non-bonding interactions between the substrate and the chiral catalyst complex. These selectivity-determining interactions might be modified through coordination of solvent, additive, or product molecules to the iridium complex, providing a rationale for the effect of solvent or additives on the enantioselectivity." @default.
- W2099872783 created "2016-06-24" @default.
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- W2099872783 date "2015-05-27" @default.
- W2099872783 modified "2023-09-27" @default.
- W2099872783 title "ChemInform Abstract: Enantioselective Imine Hydrogenation with Iridium-Catalysts: Reactions, Mechanisms and Stereocontrol" @default.
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- W2099872783 doi "https://doi.org/10.1002/chin.201524266" @default.
- W2099872783 hasPublicationYear "2015" @default.
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