FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099883737> ?p ?o ?g. }

• W2099883737 endingPage "1943" @default.
• W2099883737 startingPage "1936" @default.
• W2099883737 abstract "Cytokines are recognized as critical early mediators of organ injury. We attempted to determine whether or not severe hepatic ischemia/reperfusion injury results in tumor necrosis factor-alpha (TNF-alpha) release with subsequent local and systemic tissue injury. After 90 min of lobar hepatic ischemia, TNF was measurable during the reperfusion period in the plasma of all 14 experimental animals, with levels peaking between 9 and 352 pg/ml. Endotoxin was undetectable in the plasma of these animals. Pulmonary injury, as evidenced by a neutrophilic infiltrate, edema and intra-alveolar hemorrhage developed after hepatic reperfusion. The neutrophilic infiltrate was quantitated using a myeloperoxidase (MPO) assay; this demonstrated a significant increase in MPO after only 1 h of reperfusion. Anti-TNF antiserum pretreatment significantly reduced the pulmonary MPO after hepatic reperfusion. After a 12-h reperfusion period, there was histologic evidence of intra-alveolar hemorrhage and pulmonary edema. Morphometric assessment showed that pretreatment with anti-TNF antiserum was able to completely inhibit the development of pulmonary edema. Liver injury was quantitated by measuring serum glutamic pyruvic transaminase which showed peaks at 3 and 24 h. Anti-TNF antiserum pretreatment was able to significantly reduce both of these peak elevations. These data show that hepatic ischemia/reperfusion results in TNF production, and that this TNF is intimately associated with pulmonary and hepatic injury." @default.
• W2099883737 created "2016-06-24" @default.
• W2099883737 creator A5004928457 @default.
• W2099883737 creator A5004985444 @default.
• W2099883737 creator A5035538000 @default.
• W2099883737 creator A5039409631 @default.
• W2099883737 creator A5046357463 @default.
• W2099883737 creator A5066378306 @default.
• W2099883737 date "1990-06-01" @default.
• W2099883737 modified "2023-10-04" @default.
• W2099883737 title "Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat." @default.
• W2099883737 cites W1542084647 @default.
• W2099883737 cites W1557653296 @default.
• W2099883737 cites W1576430359 @default.
• W2099883737 cites W1968713831 @default.
• W2099883737 cites W1969411212 @default.
• W2099883737 cites W1969719203 @default.
• W2099883737 cites W1973313699 @default.
• W2099883737 cites W1982765934 @default.
• W2099883737 cites W1994067722 @default.
• W2099883737 cites W1996794055 @default.
• W2099883737 cites W2003673873 @default.
• W2099883737 cites W2011291552 @default.
• W2099883737 cites W2013114215 @default.
• W2099883737 cites W2031112820 @default.
• W2099883737 cites W2038067061 @default.
• W2099883737 cites W2038434279 @default.
• W2099883737 cites W2042980077 @default.
• W2099883737 cites W2056225363 @default.
• W2099883737 cites W2072036820 @default.
• W2099883737 cites W2072196714 @default.
• W2099883737 cites W2072863715 @default.
• W2099883737 cites W2081946593 @default.
• W2099883737 cites W2083265608 @default.
• W2099883737 cites W2090796233 @default.
• W2099883737 cites W2101157641 @default.
• W2099883737 cites W2107396956 @default.
• W2099883737 cites W2107907376 @default.
• W2099883737 cites W2126342903 @default.
• W2099883737 cites W2133614172 @default.
• W2099883737 cites W2140769991 @default.
• W2099883737 cites W2148000616 @default.
• W2099883737 cites W2304531976 @default.
• W2099883737 cites W2323870293 @default.
• W2099883737 cites W2344995500 @default.
• W2099883737 cites W2398841109 @default.
• W2099883737 cites W2411839254 @default.
• W2099883737 cites W2413649635 @default.
• W2099883737 cites W2418275479 @default.
• W2099883737 cites W2418636378 @default.
• W2099883737 cites W83022700 @default.
• W2099883737 doi "https://doi.org/10.1172/jci114656" @default.
• W2099883737 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/296661" @default.
• W2099883737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2161433" @default.
• W2099883737 hasPublicationYear "1990" @default.
• W2099883737 type Work @default.
• W2099883737 sameAs 2099883737 @default.
• W2099883737 citedByCount "805" @default.
• W2099883737 countsByYear W20998837372012 @default.
• W2099883737 countsByYear W20998837372013 @default.
• W2099883737 countsByYear W20998837372014 @default.
• W2099883737 countsByYear W20998837372015 @default.
• W2099883737 countsByYear W20998837372016 @default.
• W2099883737 countsByYear W20998837372017 @default.
• W2099883737 countsByYear W20998837372018 @default.
• W2099883737 countsByYear W20998837372019 @default.
• W2099883737 countsByYear W20998837372020 @default.
• W2099883737 countsByYear W20998837372021 @default.
• W2099883737 countsByYear W20998837372022 @default.
• W2099883737 countsByYear W20998837372023 @default.
• W2099883737 crossrefType "journal-article" @default.
• W2099883737 hasAuthorship W2099883737A5004928457 @default.
• W2099883737 hasAuthorship W2099883737A5004985444 @default.
• W2099883737 hasAuthorship W2099883737A5035538000 @default.
• W2099883737 hasAuthorship W2099883737A5039409631 @default.
• W2099883737 hasAuthorship W2099883737A5046357463 @default.
• W2099883737 hasAuthorship W2099883737A5066378306 @default.
• W2099883737 hasBestOaLocation W20998837371 @default.
• W2099883737 hasConcept C10162356 @default.
• W2099883737 hasConcept C126322002 @default.
• W2099883737 hasConcept C142724271 @default.
• W2099883737 hasConcept C17991360 @default.
• W2099883737 hasConcept C181199279 @default.
• W2099883737 hasConcept C185592680 @default.
• W2099883737 hasConcept C203565725 @default.
• W2099883737 hasConcept C2776468924 @default.
• W2099883737 hasConcept C2776877979 @default.
• W2099883737 hasConcept C2776914184 @default.
• W2099883737 hasConcept C2777714996 @default.
• W2099883737 hasConcept C2780114680 @default.
• W2099883737 hasConcept C2780886150 @default.
• W2099883737 hasConcept C503630168 @default.
• W2099883737 hasConcept C541997718 @default.
• W2099883737 hasConcept C55493867 @default.
• W2099883737 hasConcept C71924100 @default.
• W2099883737 hasConceptScore W2099883737C10162356 @default.
• W2099883737 hasConceptScore W2099883737C126322002 @default.
• W2099883737 hasConceptScore W2099883737C142724271 @default.

• next