FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099897267> ?p ?o ?g. }

• W2099897267 endingPage "168" @default.
• W2099897267 startingPage "162" @default.
• W2099897267 abstract "Several pathogenic fungi and protozoa are known to have sterols distinct from those of their mammalian hosts. Of particular interest as targets for drug development are the biosyntheses of the sterols of important parasites such as the kinetoplastid flagellates and the AIDS-associated opportunistic protist Pneumocystis carinii. These pathogens synthesize sterols with an alkyl group at C-24, and some have a double bond at C-22 of the side chain. Humans and other mammalian hosts are incapable of C-24 alkylation and C-22 desaturation. In the present study, three steroidal compounds with side chains substituted by phosphonyl-linked groups were synthesized and tested for their effects on Leishmania donovani and L. mexicana mexicana culture growth. The compounds inhibited organism proliferation at concentrations in micrograms per milliliter. The most potent inhibitors of this group of compounds were characterized by two ethyl groups at the phosphate function. Leishmania organisms treated with 17-[2-(diethylphosphonato) ethylidienyl]3-methoxy-19-norpregna-1,3,5-triene exhibited reduced growth after transfer into inhibitor-free medium. Because there are currently no axenic methods available for the continuous subcultivation of P. carinii, the effects of these drugs on this organism were evaluated by two alternative screening methods. The same two diethyl phosphonosteroid compounds that inhibited Leishmania proliferation were also the most active against P. carinii as determined by the potent effect they had on reducing cellular ATP content. Cystic as well as trophic forms responded to the drug treatments, as evaluated by a dual fluorescent staining live-dead assay. Other modifications of steroidal phosphonates may lead to the development of related drugs with increased activity and specificity for the pathogens." @default.
• W2099897267 created "2016-06-24" @default.
• W2099897267 creator A5015774072 @default.
• W2099897267 creator A5019537962 @default.
• W2099897267 creator A5043269286 @default.
• W2099897267 creator A5049385578 @default.
• W2099897267 creator A5061431435 @default.
• W2099897267 creator A5068332712 @default.
• W2099897267 creator A5091251054 @default.
• W2099897267 date "1997-01-01" @default.
• W2099897267 modified "2023-10-18" @default.
• W2099897267 title "Effects of steroidal allenic phosphonic acid derivatives on the parasitic protists Leishmania donovani, Leishmania mexicana mexicana, and Pneumocystis carinii carinii" @default.
• W2099897267 cites W1545043842 @default.
• W2099897267 cites W1776639034 @default.
• W2099897267 cites W182415355 @default.
• W2099897267 cites W1955367002 @default.
• W2099897267 cites W1976272085 @default.
• W2099897267 cites W2015245396 @default.
• W2099897267 cites W2046348452 @default.
• W2099897267 cites W2060610613 @default.
• W2099897267 cites W2086833347 @default.
• W2099897267 cites W2131953234 @default.
• W2099897267 cites W2145109675 @default.
• W2099897267 cites W2146335593 @default.
• W2099897267 cites W2161681388 @default.
• W2099897267 cites W2347088699 @default.
• W2099897267 cites W31315405 @default.
• W2099897267 doi "https://doi.org/10.1128/aac.41.1.162" @default.
• W2099897267 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/163678" @default.
• W2099897267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8980773" @default.
• W2099897267 hasPublicationYear "1997" @default.
• W2099897267 type Work @default.
• W2099897267 sameAs 2099897267 @default.
• W2099897267 citedByCount "10" @default.
• W2099897267 countsByYear W20998972672015 @default.
• W2099897267 countsByYear W20998972672017 @default.
• W2099897267 countsByYear W20998972672018 @default.
• W2099897267 crossrefType "journal-article" @default.
• W2099897267 hasAuthorship W2099897267A5015774072 @default.
• W2099897267 hasAuthorship W2099897267A5019537962 @default.
• W2099897267 hasAuthorship W2099897267A5043269286 @default.
• W2099897267 hasAuthorship W2099897267A5049385578 @default.
• W2099897267 hasAuthorship W2099897267A5061431435 @default.
• W2099897267 hasAuthorship W2099897267A5068332712 @default.
• W2099897267 hasAuthorship W2099897267A5091251054 @default.
• W2099897267 hasBestOaLocation W20998972671 @default.
• W2099897267 hasConcept C136764020 @default.
• W2099897267 hasConcept C159047783 @default.
• W2099897267 hasConcept C203014093 @default.
• W2099897267 hasConcept C2776555147 @default.
• W2099897267 hasConcept C2777559004 @default.
• W2099897267 hasConcept C2778048844 @default.
• W2099897267 hasConcept C2778265057 @default.
• W2099897267 hasConcept C2778566189 @default.
• W2099897267 hasConcept C2778689377 @default.
• W2099897267 hasConcept C2779121891 @default.
• W2099897267 hasConcept C2781092759 @default.
• W2099897267 hasConcept C2781333301 @default.
• W2099897267 hasConcept C2781371782 @default.
• W2099897267 hasConcept C2993443204 @default.
• W2099897267 hasConcept C3013748606 @default.
• W2099897267 hasConcept C3019824283 @default.
• W2099897267 hasConcept C41008148 @default.
• W2099897267 hasConcept C523546767 @default.
• W2099897267 hasConcept C54355233 @default.
• W2099897267 hasConcept C55493867 @default.
• W2099897267 hasConcept C71928629 @default.
• W2099897267 hasConcept C86803240 @default.
• W2099897267 hasConcept C89423630 @default.
• W2099897267 hasConceptScore W2099897267C136764020 @default.
• W2099897267 hasConceptScore W2099897267C159047783 @default.
• W2099897267 hasConceptScore W2099897267C203014093 @default.
• W2099897267 hasConceptScore W2099897267C2776555147 @default.
• W2099897267 hasConceptScore W2099897267C2777559004 @default.
• W2099897267 hasConceptScore W2099897267C2778048844 @default.
• W2099897267 hasConceptScore W2099897267C2778265057 @default.
• W2099897267 hasConceptScore W2099897267C2778566189 @default.
• W2099897267 hasConceptScore W2099897267C2778689377 @default.
• W2099897267 hasConceptScore W2099897267C2779121891 @default.
• W2099897267 hasConceptScore W2099897267C2781092759 @default.
• W2099897267 hasConceptScore W2099897267C2781333301 @default.
• W2099897267 hasConceptScore W2099897267C2781371782 @default.
• W2099897267 hasConceptScore W2099897267C2993443204 @default.
• W2099897267 hasConceptScore W2099897267C3013748606 @default.
• W2099897267 hasConceptScore W2099897267C3019824283 @default.
• W2099897267 hasConceptScore W2099897267C41008148 @default.
• W2099897267 hasConceptScore W2099897267C523546767 @default.
• W2099897267 hasConceptScore W2099897267C54355233 @default.
• W2099897267 hasConceptScore W2099897267C55493867 @default.
• W2099897267 hasConceptScore W2099897267C71928629 @default.
• W2099897267 hasConceptScore W2099897267C86803240 @default.
• W2099897267 hasConceptScore W2099897267C89423630 @default.
• W2099897267 hasIssue "1" @default.
• W2099897267 hasLocation W20998972671 @default.
• W2099897267 hasLocation W20998972672 @default.
• W2099897267 hasLocation W20998972673 @default.
• W2099897267 hasLocation W20998972674 @default.
• W2099897267 hasOpenAccess W2099897267 @default.

• next