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- W2099949500 abstract "Although up to half of all individuals with heart failure (HF) are said to have a preserved ejection fraction (HF-PEF), until recently only two sizeable, randomized placebo-controlled trials have been conducted in these patients ( Tables 1 and 2 ).1–3 This small number compares with more than 20 trials in patients with a low EF. It is easy, therefore, to understand why the results of the Perindopril for Elderly People with Chronic Heart Failure (PEP-CHF) have been eagerly awaited.4,5View this table: Table 1 Large trials in HF-PEFView this table: Table 2 Baseline characteristics in trials of HF-PEFThe PEP-CHF investigators are to be congratulated for randomizing patients similar to those in epidemiological studies, a feat rarely achieved in prior trials in HF ( Table 2 ). Indeed, patients with HF-PEF have proved to be harder to enrol in trials than patients with low EF, either because they are not as common as the epidemiological evidence suggests or because extreme age, frailty, and co-morbidity led to their exclusion (or both). Patients with HF-PEP in trials have also exhibited lower mortality and morbidity rates than anticipated from epidemiological studies and compared to patients with a … *Corresponding author. Tel: +44 141 330 3479; fax: +44 141 330 6955. E-mail address : j.mcmurray{at}bio.gla.ac.uk" @default.
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- W2099949500 date "2006-10-01" @default.
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- W2099949500 title "Renin angiotensin blockade in heart failure with preserved ejection fraction: the signal gets stronger" @default.
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- W2099949500 doi "https://doi.org/10.1093/eurheartj/ehl249" @default.
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