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• W2099960100 abstract "IGF-I is important for postnatal body growth and exhibits insulin-like effects on carbohydrate metabolism. The function of liver-derived IGF-I is still not established, although we previously demonstrated that liver-derived IGF-I is not required for postnatal body growth. Mice whose IGF-I gene in the liver was inactivated at 24 days of age were used to investigate the long-term role of liver-derived IGF-I for carbohydrate and lipid metabolism. Serum levels of leptin in these mice were increased by &gt;100% at 3 months of age, whereas the fat mass of the mice was decreased by 25% at 13 months of age. The mice became markedly hyperinsulinemic and yet normoglycemic, indicating an adequately compensated insulin resistance. Furthermore, they had increased serum levels of cholesterol. We conclude that liver-derived IGF-I is of importance for carbohydrate and lipid metabolism." @default.
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• W2099960100 date "2001-07-01" @default.
• W2099960100 modified "2023-10-16" @default.
• W2099960100 title "Liver-Derived IGF-I is of Importance for Normal Carbohydrate and Lipid Metabolism" @default.
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• W2099960100 doi "https://doi.org/10.2337/diabetes.50.7.1539" @default.
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