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- W2099967698 abstract "The role of nitric oxide (NO) in skin microvessels is unclear because of the variable effects of NG-monomethyl-L-arginine (L-NMMA) on skin blood flow. 1 Coffman JD Effects of endothelium-derived nitric oxide on skin and digital flow in humans. Am J Physiol. 1994; 267: 2087-2090 Google Scholar , 2 Noon JP Haynes WG Webb DJ Shore AC Local inhibition of nitric oxide generation in man reduces blood flow in finger pulp but not in hand dorsum skin. J Physiol. 1996; 490: 501-508 PubMed Google Scholar Although 80–90% of skin blood flow serves a thermoregulatory function, it is the nutritional component that is clinically important. Nitrovasodilators, such as sodium nitroprusside and glyceryl trinitrate, are difficult to study in cutaneous microvessels because they require extensive metabolism before they release NO. S-nitrosothiols release NO and are vasodilators in animals. 3 Bauer JA Fung HL Differential hemodynamic effects and tolerance properties of nitroglycerine and S-nitrosothiol in experimental heart failure. J Pharmacol Exp Ther. 1991; 256: 249-254 PubMed Google Scholar S-nitrosothio-acetylglucose (SNAG) acts as a vasodilator in the isolated rat tail artery. 4 Butler AR, Field RA, Greig IR, et al. An examination of some derivatives of S-nitroso-I-thiosugars as vasodilators. Nitric Oxide Biol Chem (in press). Google Scholar We now examine the effects of transdermal application of SNAG on human skin microvessels. We measured skin perfusion with laser doppler imaging and skin oxygenation by lightguide spectrophotometry." @default.
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- W2099967698 date "1997-08-01" @default.
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- W2099967698 title "Skin blood flow after transdermal S-nitrosothio-acetylglucose" @default.
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- W2099967698 doi "https://doi.org/10.1016/s0140-6736(05)64133-5" @default.
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