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- W209997589 abstract "This chapter focuses on bioelectricity and cartilage. Naturally occurring electrical potentials can be recorded from cartilages and their constituent cells, and cartilages such as epiphyseal growth plate and articular exhibit electrical polarization, with the actively growing sites being more electronegative. Mechanical deformation of cartilage alters its inherent electrical activity so that it becomes more electronegative. Physical forces may be transduced into electrical activity to which cartilage can respond. Electronegativity is associated with growth, morphogenesis, reparative, and regenerative processes in cartilage. Cartilage can respond to electrical currents. This is true whether the currents are applied in vivo by implanting electrodes or in vitro by culturing cartilage in electrical fields. In vitro, the response involves proliferation and increases synthesis and deposition of extracellular matrix products. In vivo, the response can lead to regeneration of cartilage in amputated appendages or to repair of fractures by cartilage. Cartilage can also respond to electromagnetic fields. Such fields do not stimulate proliferation but do stimulate collagen synthesis and have a profound effect on calcification of cartilage. Electrical fields are better suited to situations such as regeneration of appendages or repair of articular cartilage where proliferation, dedifferentiation, and redifferentiation of cells is required. Electrical fields may also act indirectly by modifying local oxygen tension and pH levels, which in turn would have considerable effect upon a relatively anaerobic tissue with the low oxygen consumption of cartilage." @default.
- W209997589 created "2016-06-24" @default.
- W209997589 creator A5030522587 @default.
- W209997589 date "1983-01-01" @default.
- W209997589 modified "2023-10-16" @default.
- W209997589 title "Bioelectricity and Cartilage" @default.
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- W209997589 doi "https://doi.org/10.1016/b978-0-12-319503-6.50016-5" @default.
- W209997589 hasPublicationYear "1983" @default.
- W209997589 type Work @default.