Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099976714> ?p ?o ?g. }
- W2099976714 endingPage "846" @default.
- W2099976714 startingPage "839" @default.
- W2099976714 abstract "Cenp-F (also named mitosin) is a 350-kDa human kinetochore protein important for the mitotic progression. It is also a nuclear matrix protein in interphase cells. Here, we showed that overexpression of N-terminal deletion mutants of Cenp-F containing the C-terminal 112 residues induced chromatin condensation into numerous aggregates of varying sizes in interphase nucleus, colocalizing with the exogenous proteins. In situ hybridization using whole chromosome painting probes indicated that the chromatin aggregates were not prematurely condensed individual chromosomes. Neither were they due to apoptosis. We provided evidence showing association of Cenp-F with certain regions of interphase chromatin fibers. Cenp-F associated with the DNA-dependent protein kinase (DNA-PK), a trimeric protein complex critical for genome homeostasis. Moreover, the DNA-PK association activity of Cenp-F mutants correlated with their ability to induce chromatin aggregation. These results imply a role of Cenp-F in organization of interphase chromatin through association and possibly regulation of DNA-PK." @default.
- W2099976714 created "2016-06-24" @default.
- W2099976714 creator A5013155691 @default.
- W2099976714 creator A5021293751 @default.
- W2099976714 creator A5047305812 @default.
- W2099976714 creator A5088127595 @default.
- W2099976714 creator A5091688695 @default.
- W2099976714 date "2010-12-01" @default.
- W2099976714 modified "2023-09-23" @default.
- W2099976714 title "Involvement of Cenp-F in interphase chromatin organization possibly through association with DNA-dependent protein kinase" @default.
- W2099976714 cites W1966305735 @default.
- W2099976714 cites W1969415325 @default.
- W2099976714 cites W1998147517 @default.
- W2099976714 cites W1998728980 @default.
- W2099976714 cites W2004855758 @default.
- W2099976714 cites W2005393972 @default.
- W2099976714 cites W2013906792 @default.
- W2099976714 cites W2014071107 @default.
- W2099976714 cites W2022116509 @default.
- W2099976714 cites W2030508602 @default.
- W2099976714 cites W2031690395 @default.
- W2099976714 cites W2031840176 @default.
- W2099976714 cites W2038675022 @default.
- W2099976714 cites W2048109276 @default.
- W2099976714 cites W2057717008 @default.
- W2099976714 cites W2068176108 @default.
- W2099976714 cites W2076410226 @default.
- W2099976714 cites W2081911025 @default.
- W2099976714 cites W2100147739 @default.
- W2099976714 cites W2101117526 @default.
- W2099976714 cites W2102157113 @default.
- W2099976714 cites W2107424534 @default.
- W2099976714 cites W2108590463 @default.
- W2099976714 cites W2118490128 @default.
- W2099976714 cites W2120153758 @default.
- W2099976714 cites W2124995142 @default.
- W2099976714 cites W2141266008 @default.
- W2099976714 cites W2154294333 @default.
- W2099976714 cites W2155444606 @default.
- W2099976714 cites W2156466103 @default.
- W2099976714 cites W2166815074 @default.
- W2099976714 cites W2168213018 @default.
- W2099976714 cites W2325707043 @default.
- W2099976714 doi "https://doi.org/10.1093/abbs/gmq095" @default.
- W2099976714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20978035" @default.
- W2099976714 hasPublicationYear "2010" @default.
- W2099976714 type Work @default.
- W2099976714 sameAs 2099976714 @default.
- W2099976714 citedByCount "3" @default.
- W2099976714 countsByYear W20999767142013 @default.
- W2099976714 countsByYear W20999767142016 @default.
- W2099976714 crossrefType "journal-article" @default.
- W2099976714 hasAuthorship W2099976714A5013155691 @default.
- W2099976714 hasAuthorship W2099976714A5021293751 @default.
- W2099976714 hasAuthorship W2099976714A5047305812 @default.
- W2099976714 hasAuthorship W2099976714A5088127595 @default.
- W2099976714 hasAuthorship W2099976714A5091688695 @default.
- W2099976714 hasConcept C104317684 @default.
- W2099976714 hasConcept C105686024 @default.
- W2099976714 hasConcept C148196450 @default.
- W2099976714 hasConcept C153911025 @default.
- W2099976714 hasConcept C167227067 @default.
- W2099976714 hasConcept C178108356 @default.
- W2099976714 hasConcept C185592680 @default.
- W2099976714 hasConcept C29452124 @default.
- W2099976714 hasConcept C45413362 @default.
- W2099976714 hasConcept C54355233 @default.
- W2099976714 hasConcept C552990157 @default.
- W2099976714 hasConcept C56262557 @default.
- W2099976714 hasConcept C83640560 @default.
- W2099976714 hasConcept C86803240 @default.
- W2099976714 hasConcept C95444343 @default.
- W2099976714 hasConceptScore W2099976714C104317684 @default.
- W2099976714 hasConceptScore W2099976714C105686024 @default.
- W2099976714 hasConceptScore W2099976714C148196450 @default.
- W2099976714 hasConceptScore W2099976714C153911025 @default.
- W2099976714 hasConceptScore W2099976714C167227067 @default.
- W2099976714 hasConceptScore W2099976714C178108356 @default.
- W2099976714 hasConceptScore W2099976714C185592680 @default.
- W2099976714 hasConceptScore W2099976714C29452124 @default.
- W2099976714 hasConceptScore W2099976714C45413362 @default.
- W2099976714 hasConceptScore W2099976714C54355233 @default.
- W2099976714 hasConceptScore W2099976714C552990157 @default.
- W2099976714 hasConceptScore W2099976714C56262557 @default.
- W2099976714 hasConceptScore W2099976714C83640560 @default.
- W2099976714 hasConceptScore W2099976714C86803240 @default.
- W2099976714 hasConceptScore W2099976714C95444343 @default.
- W2099976714 hasIssue "12" @default.
- W2099976714 hasLocation W20999767141 @default.
- W2099976714 hasLocation W20999767142 @default.
- W2099976714 hasOpenAccess W2099976714 @default.
- W2099976714 hasPrimaryLocation W20999767141 @default.
- W2099976714 hasRelatedWork W1991446103 @default.
- W2099976714 hasRelatedWork W1992830050 @default.
- W2099976714 hasRelatedWork W1999261906 @default.
- W2099976714 hasRelatedWork W2063998311 @default.
- W2099976714 hasRelatedWork W2096065245 @default.
- W2099976714 hasRelatedWork W2099976714 @default.