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• W2099982440 abstract "Resistance mechanisms selected after in vitro exposure to 12 quinolones were analyzed for Pseudomonas aeruginosa. Efflux-type mutants were predominant. Quinolones differed in their ability to select a particular efflux system. While the newer fluoroquinolones favored the MexCD-OprJ system, the older quinolones selected exclusively the MexEF-OprN or MexAB-OprM systems. A protonable C-7 substituent in combination with a C-6 fluorine atom is a structural determinant of quinolones involved in efflux pump substrate specificity." @default.
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• W2099982440 date "1997-11-01" @default.
• W2099982440 modified "2023-10-17" @default.
• W2099982440 title "Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa" @default.
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• W2099982440 doi "https://doi.org/10.1128/aac.41.11.2540" @default.
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