Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100000068> ?p ?o ?g. }
- W2100000068 endingPage "1643" @default.
- W2100000068 startingPage "1635" @default.
- W2100000068 abstract "Complement activation contributes directly to health and disease. It neutralizes pathogens and stimulates immune processes. Defects lead to immunodeficiency and autoimmune diseases, whereas inappropriate activation causes self-damage. In the lectin and classical pathways, complement is triggered upon recognition of a pathogen by an activating complex. Here we present the first structure of such a complex in the form of the collagen-like domain of mannan-binding lectin (MBL) and the binding domain of its associated protease (MASP-1/-3). The collagen binds within a groove using a pivotal lysine side chain that interacts with Ca2+-coordinating residues, revealing the essential role of Ca2+. This mode of binding is prototypic for all activating complexes of the lectin and classical pathways, and suggests a general mechanism for the global changes that drive activation. The structural insights reveal a new focus for inhibitors and we have validated this concept by targeting the binding pocket of the MASP." @default.
- W2100000068 created "2016-06-24" @default.
- W2100000068 creator A5007250505 @default.
- W2100000068 creator A5010096918 @default.
- W2100000068 creator A5022037509 @default.
- W2100000068 creator A5028623683 @default.
- W2100000068 creator A5047095751 @default.
- W2100000068 creator A5058073302 @default.
- W2100000068 creator A5081163110 @default.
- W2100000068 date "2011-11-01" @default.
- W2100000068 modified "2023-10-10" @default.
- W2100000068 title "Structural Basis of Mannan-Binding Lectin Recognition by Its Associated Serine Protease MASP-1: Implications for Complement Activation" @default.
- W2100000068 cites W121388512 @default.
- W2100000068 cites W1574595419 @default.
- W2100000068 cites W1939603229 @default.
- W2100000068 cites W1963858490 @default.
- W2100000068 cites W1965901007 @default.
- W2100000068 cites W1979221090 @default.
- W2100000068 cites W1983326491 @default.
- W2100000068 cites W1991163875 @default.
- W2100000068 cites W1991504286 @default.
- W2100000068 cites W1995925239 @default.
- W2100000068 cites W1996033641 @default.
- W2100000068 cites W2000840258 @default.
- W2100000068 cites W2002178602 @default.
- W2100000068 cites W2003111769 @default.
- W2100000068 cites W2006720282 @default.
- W2100000068 cites W2030385147 @default.
- W2100000068 cites W2044426320 @default.
- W2100000068 cites W2047500306 @default.
- W2100000068 cites W2056141658 @default.
- W2100000068 cites W2056444232 @default.
- W2100000068 cites W2057217334 @default.
- W2100000068 cites W2061147238 @default.
- W2100000068 cites W2064001879 @default.
- W2100000068 cites W2067217824 @default.
- W2100000068 cites W2067957598 @default.
- W2100000068 cites W2077008485 @default.
- W2100000068 cites W2086049041 @default.
- W2100000068 cites W2106541600 @default.
- W2100000068 cites W2111457654 @default.
- W2100000068 cites W2113038626 @default.
- W2100000068 cites W2116775934 @default.
- W2100000068 cites W2141556439 @default.
- W2100000068 cites W2149383583 @default.
- W2100000068 cites W2152518726 @default.
- W2100000068 cites W2155607098 @default.
- W2100000068 cites W2160795660 @default.
- W2100000068 cites W2162562269 @default.
- W2100000068 cites W2173015905 @default.
- W2100000068 doi "https://doi.org/10.1016/j.str.2011.08.014" @default.
- W2100000068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22078562" @default.
- W2100000068 hasPublicationYear "2011" @default.
- W2100000068 type Work @default.
- W2100000068 sameAs 2100000068 @default.
- W2100000068 citedByCount "56" @default.
- W2100000068 countsByYear W21000000682012 @default.
- W2100000068 countsByYear W21000000682013 @default.
- W2100000068 countsByYear W21000000682014 @default.
- W2100000068 countsByYear W21000000682015 @default.
- W2100000068 countsByYear W21000000682016 @default.
- W2100000068 countsByYear W21000000682017 @default.
- W2100000068 countsByYear W21000000682018 @default.
- W2100000068 countsByYear W21000000682019 @default.
- W2100000068 countsByYear W21000000682020 @default.
- W2100000068 countsByYear W21000000682021 @default.
- W2100000068 countsByYear W21000000682022 @default.
- W2100000068 countsByYear W21000000682023 @default.
- W2100000068 crossrefType "journal-article" @default.
- W2100000068 hasAuthorship W2100000068A5007250505 @default.
- W2100000068 hasAuthorship W2100000068A5010096918 @default.
- W2100000068 hasAuthorship W2100000068A5022037509 @default.
- W2100000068 hasAuthorship W2100000068A5028623683 @default.
- W2100000068 hasAuthorship W2100000068A5047095751 @default.
- W2100000068 hasAuthorship W2100000068A5058073302 @default.
- W2100000068 hasAuthorship W2100000068A5081163110 @default.
- W2100000068 hasBestOaLocation W21000000681 @default.
- W2100000068 hasConcept C106257327 @default.
- W2100000068 hasConcept C111684460 @default.
- W2100000068 hasConcept C124594742 @default.
- W2100000068 hasConcept C133493029 @default.
- W2100000068 hasConcept C136449434 @default.
- W2100000068 hasConcept C170493617 @default.
- W2100000068 hasConcept C171279029 @default.
- W2100000068 hasConcept C181199279 @default.
- W2100000068 hasConcept C185592680 @default.
- W2100000068 hasConcept C189413060 @default.
- W2100000068 hasConcept C203014093 @default.
- W2100000068 hasConcept C203880312 @default.
- W2100000068 hasConcept C2776414213 @default.
- W2100000068 hasConcept C2776714187 @default.
- W2100000068 hasConcept C2777807008 @default.
- W2100000068 hasConcept C2780758401 @default.
- W2100000068 hasConcept C51639874 @default.
- W2100000068 hasConcept C55493867 @default.
- W2100000068 hasConcept C82553315 @default.
- W2100000068 hasConcept C86803240 @default.
- W2100000068 hasConcept C8891405 @default.