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• W2100017537 startingPage "1080" @default.
• W2100017537 abstract "Luminal nutrients and growth factors regulate postresectional intestinal growth. The interplay between glutamine and regulatory gastrointestinal peptides is not known.The effects of intestinal resection on tissue and plasma concentrations of peptides were studied in 60 Sprague-Dawley rats divided into resected, transected, or unoperated groups. Subgroups were fed either a glutamine-free or a glutamine-supplemented diet for 7 days. Epidermal growth factor, transforming growth factor-alpha, insulin-like growth factors (IGF) I and II, peptide YY (PYY), and enteroglucagon were analyzed in intestinal mucosa and in portal plasma by radioimmunoassay.No glutamine-specific effects were seen. The mucosal content of IGF-II (P < 0.01) and the portal levels of enteroglucagon and PYY (P < 0.05-0.01) increased after intestinal resection.The increase in PYY and enteroglucagon in portal blood supports a hormonal role in the postresectional adaptation. The increase in IGF II in the ileal mucosa, without changes in plasma, implies autocrine or paracrine growth stimulation at this stage after resection." @default.
• W2100017537 created "2016-06-24" @default.
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• W2100017537 date "1998-01-01" @default.
• W2100017537 modified "2023-09-26" @default.
• W2100017537 title "An Increase in Mucosal Insulin-like Growth Factor II Content in Postresectional Rat Intestine Suggests Autocrine or Paracrine Growth Stimulation" @default.
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• W2100017537 doi "https://doi.org/10.1080/003655298750026796" @default.
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