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- W2100021679 abstract "The ability of axons to regenerate after a nerve lesion provides an opportunity for studying in the adult animal factors that govern the specificity of neural connections. In many animals, particularly among the lower vertebrates, regenerating axons preferentially reinnervate their original targets (for reviews, see Gaze 1970; Jacobsen 1970). This specificity may well be mediated by a combination of mechanisms, such as guidance toward the proper destination by growth along appropriate chemical gradients and a specific chemoaffinity between cells that form connections (Sperry 1963). It is not easy, however, to assess the relative importance of these and other possible mechanisms. Nor has it been clear just how precise the connections formed during reinnervation can be— whether, for example, neurons are able to recognize one another on an individual cell-to-cell basis." @default.
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- W2100021679 date "1976-01-01" @default.
- W2100021679 modified "2023-09-25" @default.
- W2100021679 title "Repair of Specific Neuronal Pathways in the Leech" @default.
- W2100021679 doi "https://doi.org/10.1101/sqb.1976.040.01.046" @default.
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