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- W2100021845 abstract "Mammals supply their newborn before birth, at birth or shortly after birth with antibodies, immunocytes and humoral constituents. This borrowed immunity is a form of passive immunization to protect the newborn against environmental pathogens until it establishes its own pathogen recognition and disposal systems. In cows, goats, horses and some other animal species, most immunoglobulins are obtained from the colostrum, the first milk after birth, via the gut but in humans the majority of immunoglobulins, and those of the IgG-class in particular, are acquired from the mother by placental transport in the weeks prior to parturition. It has long been known that the consumption of bovine colostrum by humans has therapeutic effects e.g. in gastrointestinal infections, but only since the second half of the last century has it been possible to prepare stable, standardized preparations of colostrum. These biologics are administered to patients in combination with standard therapies as so-called balanced supportive diets. Investigations with standardized colostrum preparations in animal models of human disease and estimates of bovine IgG activity in the human GI-tract, described in this review, have provided preclinical data supporting the use of bovine colostrum in human diseases. On the other hand, the number of bovine colostrum products with a sufficiently large and reliable database is limited and the precise nature of the therapeutic targets is still being evaluated." @default.
- W2100021845 created "2016-06-24" @default.
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- W2100021845 date "2007-04-01" @default.
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- W2100021845 title "Bovine colostrum as a biologic in clinical medicine: a review.Part I: Biotechnological standards, pharmacodynamic and pharmacokinetic characteristics and principles of treatment" @default.
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- W2100021845 doi "https://doi.org/10.5414/cpp45193" @default.
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