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- W2100021866 abstract "Synthesis and biological assays of a series of 2-phenylpteridine derivatives are described to compare their affinities to adenosine receptors with those of the corresponding adenines, purposely prepared, and 8-azaadenines previously described. This study demonstrates that the enlargement of the five-membered ring of the adenine nucleus to a six-membered one is a modification that does not allow the molecules to maintain high activity towards adenosine receptors; in fact, pteridine derivatives did not show themselves to be good adenosine receptor ligands. On the contrary, N6-cycloalkyl- or N6-alkyl-2-phenyladenines showed a very high affinity and selectivity for A1 adenosine receptors. We demonstrate also that the 9-benzyl substituent is crucial for conferring high affinity for A3 receptors to molecules having a 2-phenyladenine-like nucleus." @default.
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- W2100021866 date "2007-02-01" @default.
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- W2100021866 title "Synthesis of New 2-Phenyladenines and 2-Phenylpteridines and Biological Evaluation as Adenosine Receptor Ligands" @default.
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- W2100021866 doi "https://doi.org/10.1002/ardp.200600168" @default.
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