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• W2100022470 abstract "To determine the source of circulating inhibin and estradiol-17β during the estrous cycle in mares, the cellular localization of the inhibin α, βA, and βB subunits and aromatase in the ovary was determined by immunohistochemistry. Concentrations of immunoreactive (ir-) inhibin, estradiol-17β, progesterone, LH, and FSH in peripheral blood were also measured during the estrous cycle in mares. Immunohistochemically, inhibin α subunits were localized in the granulosa cells of small and large follicles and in the theca interna cells of large follicles, whereas inhibin βA and βB subunits were localized in the granulosa cells and in the theca interna cells of large follicles. On the other hand, aromatase was restricted to only the granulosa cells of large follicles. Plasma ir-inhibin concentrations began to increase 9 days before ovulation; they remained high until 2 days before ovulation, after which they decreased when the LH surge was initiated. Thereafter, a further sharp rise in circulating ir-inhibin concentrations occurred during the process of ovulation, followed by a second abrupt decline. After the decline, plasma concentrations of ir-inhibin remained low during the luteal phase. Plasma estradiol-17β concentrations followed a profile similar to that of ir-inhibin, except during ovulation, and these two hormones were positively correlated throughout the estrous cycle. Plasma FSH concentrations were inversely related to ir-inhibin and estradiol-17β. These findings suggest that the dimeric inhibin is mainly secreted by the granulosa cells and the theca cells of large follicles; granulosa cells of small follicles may secrete inhibin α subunit, and estradiol-17β is secreted by the granulosa cells of only large follicles in mares." @default.
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• W2100022470 date "1998-12-01" @default.
• W2100022470 modified "2023-09-23" @default.
• W2100022470 title "Inhibin Secretion in the Mare: Localization of Inhibin α, βA, and βB Subunits in the Ovary1" @default.
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• W2100022470 doi "https://doi.org/10.1095/biolreprod59.6.1392" @default.
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