FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100023008> ?p ?o ?g. }

• W2100023008 endingPage "797" @default.
• W2100023008 startingPage "784" @default.
• W2100023008 abstract "NADPH oxidase (Nox) enzymes are a significant source of reactive oxygen species, which contribute to glomerular podocyte dysfunction. Although studies have implicated Nox1, -2, and -4 in several glomerulopathies, including diabetic nephropathy, little is known regarding the role of Nox5 in this context. We examined Nox5 expression and regulation in kidney biopsies from diabetic patients, cultured human podocytes, and a novel mouse model. Nox5 expression increased in human diabetic glomeruli compared with nondiabetic glomeruli. Stimulation with angiotensin II upregulated Nox5 expression in human podocyte cultures and increased reactive oxygen species generation. siRNA-mediated Nox5 knockdown inhibited angiotensin II–stimulated production of reactive oxygen species and altered podocyte cytoskeletal dynamics, resulting in an Rac-mediated motile phenotype. Because the Nox5 gene is absent in rodents, we generated transgenic mice expressing human Nox5 in a podocyte-specific manner (Nox5pod+). Nox5pod+ mice exhibited early onset albuminuria, podocyte foot process effacement, and elevated systolic BP. Subjecting Nox5pod+ mice to streptozotocin-induced diabetes further exacerbated these changes. Our data show that renal Nox5 is upregulated in human diabetic nephropathy and may alter filtration barrier function and systolic BP through the production of reactive oxygen species. These findings provide the first evidence that podocyte Nox5 has an important role in impaired renal function and hypertension." @default.
• W2100023008 created "2016-06-24" @default.
• W2100023008 creator A5017512470 @default.
• W2100023008 creator A5043497289 @default.
• W2100023008 creator A5047115191 @default.
• W2100023008 creator A5050768624 @default.
• W2100023008 creator A5062670268 @default.
• W2100023008 creator A5064294168 @default.
• W2100023008 creator A5066544154 @default.
• W2100023008 creator A5085366201 @default.
• W2100023008 creator A5087023625 @default.
• W2100023008 date "2014-04-01" @default.
• W2100023008 modified "2023-10-14" @default.
• W2100023008 title "Nephropathy and Elevated BP in Mice with Podocyte-Specific NADPH Oxidase 5 Expression" @default.
• W2100023008 cites W1918578504 @default.
• W2100023008 cites W1966748010 @default.
• W2100023008 cites W1977151079 @default.
• W2100023008 cites W1977424733 @default.
• W2100023008 cites W1982280480 @default.
• W2100023008 cites W1985469977 @default.
• W2100023008 cites W1987665013 @default.
• W2100023008 cites W1990549067 @default.
• W2100023008 cites W1993288994 @default.
• W2100023008 cites W1994831991 @default.
• W2100023008 cites W1996485736 @default.
• W2100023008 cites W2012258975 @default.
• W2100023008 cites W2014412160 @default.
• W2100023008 cites W2019063477 @default.
• W2100023008 cites W2027762258 @default.
• W2100023008 cites W2029818480 @default.
• W2100023008 cites W2031085640 @default.
• W2100023008 cites W2031534703 @default.
• W2100023008 cites W2032556453 @default.
• W2100023008 cites W2034541989 @default.
• W2100023008 cites W2039498672 @default.
• W2100023008 cites W2049535510 @default.
• W2100023008 cites W2055801973 @default.
• W2100023008 cites W2055821476 @default.
• W2100023008 cites W2064732202 @default.
• W2100023008 cites W2068335053 @default.
• W2100023008 cites W2069259656 @default.
• W2100023008 cites W2072546908 @default.
• W2100023008 cites W2075980045 @default.
• W2100023008 cites W2077746464 @default.
• W2100023008 cites W2079723429 @default.
• W2100023008 cites W2090951884 @default.
• W2100023008 cites W2095703659 @default.
• W2100023008 cites W2100829672 @default.
• W2100023008 cites W2102235083 @default.
• W2100023008 cites W2105940831 @default.
• W2100023008 cites W2109338235 @default.
• W2100023008 cites W2112756559 @default.
• W2100023008 cites W2115215416 @default.
• W2100023008 cites W2115724806 @default.
• W2100023008 cites W2124445444 @default.
• W2100023008 cites W2131153373 @default.
• W2100023008 cites W2136458558 @default.
• W2100023008 cites W2138002856 @default.
• W2100023008 cites W2138423356 @default.
• W2100023008 cites W2139947959 @default.
• W2100023008 cites W2146179253 @default.
• W2100023008 cites W2148303421 @default.
• W2100023008 cites W2148652246 @default.
• W2100023008 cites W2155201691 @default.
• W2100023008 cites W2155210704 @default.
• W2100023008 cites W2155859235 @default.
• W2100023008 cites W2158757718 @default.
• W2100023008 doi "https://doi.org/10.1681/asn.2013040371" @default.
• W2100023008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3968494" @default.
• W2100023008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24262797" @default.
• W2100023008 hasPublicationYear "2014" @default.
• W2100023008 type Work @default.
• W2100023008 sameAs 2100023008 @default.
• W2100023008 citedByCount "106" @default.
• W2100023008 countsByYear W21000230082014 @default.
• W2100023008 countsByYear W21000230082015 @default.
• W2100023008 countsByYear W21000230082016 @default.
• W2100023008 countsByYear W21000230082017 @default.
• W2100023008 countsByYear W21000230082018 @default.
• W2100023008 countsByYear W21000230082019 @default.
• W2100023008 countsByYear W21000230082020 @default.
• W2100023008 countsByYear W21000230082021 @default.
• W2100023008 countsByYear W21000230082022 @default.
• W2100023008 countsByYear W21000230082023 @default.
• W2100023008 crossrefType "journal-article" @default.
• W2100023008 hasAuthorship W2100023008A5017512470 @default.
• W2100023008 hasAuthorship W2100023008A5043497289 @default.
• W2100023008 hasAuthorship W2100023008A5047115191 @default.
• W2100023008 hasAuthorship W2100023008A5050768624 @default.
• W2100023008 hasAuthorship W2100023008A5062670268 @default.
• W2100023008 hasAuthorship W2100023008A5064294168 @default.
• W2100023008 hasAuthorship W2100023008A5066544154 @default.
• W2100023008 hasAuthorship W2100023008A5085366201 @default.
• W2100023008 hasAuthorship W2100023008A5087023625 @default.
• W2100023008 hasBestOaLocation W21000230081 @default.
• W2100023008 hasConcept C104317684 @default.
• W2100023008 hasConcept C126322002 @default.
• W2100023008 hasConcept C127561419 @default.

• next