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- W2100023128 abstract "LDL Receptor 1 (OLR1) gene has been shown to act as risk factor for Alzheimer's disease (AD). 1) To carry out an association analysis of OLR1 in a population of 443 patients with AD, compared with 391 age-matched controls. 2) To perform an expression analysis of OLR1 and its regulatory hsa-miR-369-3p in Peripheral Mononuclear Blood Cells (PBMC) from patients and controls. The genetic analysis was performed by allelic discrimination. The expression analysis was done by Real-time PCR. A statistically significant increased frequency of OLR1 rs1050283C allele was observed in AD patients compared with controls (46 versus 43%, P = 0.011, OR: 1.48, 95% CI: 1.10-2.00). Stratifying according to gender, a statistically increased frequency of OLR1 rs1050283C allele was observed in female AD patients as compared to female controls (51 versus 37%, P < 0.001, OR: 2.90, 95% CI: 1.97 - 4.24), but not in males. A significantly decreased relative expression level of OLR1 in PBMC was observed in AD patients carrying the rs1050283C allele (0.23±0.13 versus 0.92±0.8, P = 0.04) as compared with AD patients not carrying the C allele. Increased relative expression levels of the hsa-miR-369-3p was observed in AD patients carrying the rs1050283C allele, although the significant threshold was not reached (2.23±1.35 versus 1.16±0.31, POLR1 and hsa-miRNA-369-3p gene expression was found in AD patients carrying rs1050283C allele (r = −0.313, P = 0.05) . The OLR1 rs1050283C allele likely acts as a risk factor for sporadic AD; OLR1 and its transcriptional regulatory factor hsa-miR-369-3p are deregulated in AD patients carrying the rs1050283C allele." @default.
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- W2100023128 date "2011-07-01" @default.
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- W2100023128 title "P1-231: Role of OLR1 and Its Regulating hsa-miR369-3p in Alzheimer's Disease: Genetic and Expression Analysis" @default.
- W2100023128 doi "https://doi.org/10.1016/j.jalz.2011.05.511" @default.
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