FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100024166> ?p ?o ?g. }

• W2100024166 endingPage "979" @default.
• W2100024166 startingPage "971" @default.
• W2100024166 abstract "To determine whether the expression of transforming growth factor alpha (TGF-alpha), its receptor (epidermal growth factor receptor [EGFr]), p53 nuclear protein, and proliferation influences prognosis of patients with liver metastases, a study was performed in 45 liver metastases and 33 corresponding primary colorectal carcinomas in patients referred for liver surgery. The expression of TGF-alpha, EGFr, p53 nuclear protein, and proliferation rate was correlated with clinicopathological characteristics and survival after partial liver resection. In liver metastases, TGF-alpha expression was low in 42%, intermediate in 35%, and high in 23%. TGF-alpha expression was higher in liver metastases derived from lymph node-positive primary carcinomas, in synchronous and in irresectable liver metastases compared with those derived from lymph node-negative primary carcinomas, metachronous, and resectable liver metastases. Nuclear p53 expression was found in 83% of primary tumors and 71% of liver metastases. p53 expression did not correlate with the various clinicopathological characteristics. Ki67 expression was not associated with clinicopathological characteristics in primary and metastatic tumors. In the 38 patients in whom a partial liver resection was performed, median survival was 25 months in patients with a higher TGF-alpha expression in the metastasis than in the primary tumor and 60 months in patients with comparable or lower TGF-alpha expression in the metastasis than in the primary tumor (P = .036). Median survival after liver resection was 21 months in patients with p53-negative liver metastases and 58 months in patients with p53-positive metastases (P = .043). By multivariate analysis, p53 and EGFr expression on liver metastases were the best predictors of disease-free survival after partial liver resection, with relative risks of 2.38 and 3.33, respectively. In patients with colorectal liver metastases, referred for liver surgery, a higher TGF-alpha expression is associated with unfavorable tumor characteristics, whereas p53 and absence of EGFr expression is associated with a better survival after partial liver resection." @default.
• W2100024166 created "2016-06-24" @default.
• W2100024166 creator A5008533387 @default.
• W2100024166 creator A5015085014 @default.
• W2100024166 creator A5016301942 @default.
• W2100024166 creator A5018706155 @default.
• W2100024166 creator A5053556628 @default.
• W2100024166 creator A5061527491 @default.
• W2100024166 creator A5066224442 @default.
• W2100024166 creator A5070456340 @default.
• W2100024166 creator A5076385789 @default.
• W2100024166 date "1998-10-01" @default.
• W2100024166 modified "2023-10-16" @default.
• W2100024166 title "Clinical relevance of transforming growth factor ?, epidermal growth factor receptor, p53, and Ki67 in colorectal liver metastases and corresponding primary tumors" @default.
• W2100024166 cites W1482004139 @default.
• W2100024166 cites W1514367239 @default.
• W2100024166 cites W1615389580 @default.
• W2100024166 cites W1964337404 @default.
• W2100024166 cites W1969974964 @default.
• W2100024166 cites W1974565876 @default.
• W2100024166 cites W1975345098 @default.
• W2100024166 cites W1975433450 @default.
• W2100024166 cites W1976103210 @default.
• W2100024166 cites W1976158860 @default.
• W2100024166 cites W1980976772 @default.
• W2100024166 cites W1987563200 @default.
• W2100024166 cites W1990583954 @default.
• W2100024166 cites W1990635569 @default.
• W2100024166 cites W1998966672 @default.
• W2100024166 cites W2002678771 @default.
• W2100024166 cites W2005496035 @default.
• W2100024166 cites W2008035006 @default.
• W2100024166 cites W2008833548 @default.
• W2100024166 cites W2015599978 @default.
• W2100024166 cites W2017214707 @default.
• W2100024166 cites W2019122678 @default.
• W2100024166 cites W2020903637 @default.
• W2100024166 cites W2024082570 @default.
• W2100024166 cites W2024260681 @default.
• W2100024166 cites W2027379399 @default.
• W2100024166 cites W2045077447 @default.
• W2100024166 cites W2047350045 @default.
• W2100024166 cites W2059909963 @default.
• W2100024166 cites W2065031458 @default.
• W2100024166 cites W2070779911 @default.
• W2100024166 cites W2072027648 @default.
• W2100024166 cites W2074114909 @default.
• W2100024166 cites W2074656876 @default.
• W2100024166 cites W2082818693 @default.
• W2100024166 cites W2090157013 @default.
• W2100024166 cites W2110836068 @default.
• W2100024166 cites W2118284608 @default.
• W2100024166 cites W2125551462 @default.
• W2100024166 cites W2163185599 @default.
• W2100024166 cites W2170307166 @default.
• W2100024166 cites W2242178260 @default.
• W2100024166 cites W2331751054 @default.
• W2100024166 cites W2333252720 @default.
• W2100024166 doi "https://doi.org/10.1002/hep.510280411" @default.
• W2100024166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9755233" @default.
• W2100024166 hasPublicationYear "1998" @default.
• W2100024166 type Work @default.
• W2100024166 sameAs 2100024166 @default.
• W2100024166 citedByCount "112" @default.
• W2100024166 countsByYear W21000241662012 @default.
• W2100024166 countsByYear W21000241662013 @default.
• W2100024166 countsByYear W21000241662014 @default.
• W2100024166 countsByYear W21000241662015 @default.
• W2100024166 countsByYear W21000241662016 @default.
• W2100024166 countsByYear W21000241662017 @default.
• W2100024166 countsByYear W21000241662018 @default.
• W2100024166 countsByYear W21000241662019 @default.
• W2100024166 countsByYear W21000241662021 @default.
• W2100024166 crossrefType "journal-article" @default.
• W2100024166 hasAuthorship W2100024166A5008533387 @default.
• W2100024166 hasAuthorship W2100024166A5015085014 @default.
• W2100024166 hasAuthorship W2100024166A5016301942 @default.
• W2100024166 hasAuthorship W2100024166A5018706155 @default.
• W2100024166 hasAuthorship W2100024166A5053556628 @default.
• W2100024166 hasAuthorship W2100024166A5061527491 @default.
• W2100024166 hasAuthorship W2100024166A5066224442 @default.
• W2100024166 hasAuthorship W2100024166A5070456340 @default.
• W2100024166 hasAuthorship W2100024166A5076385789 @default.
• W2100024166 hasConcept C121608353 @default.
• W2100024166 hasConcept C125555471 @default.
• W2100024166 hasConcept C126322002 @default.
• W2100024166 hasConcept C142724271 @default.
• W2100024166 hasConcept C143998085 @default.
• W2100024166 hasConcept C170493617 @default.
• W2100024166 hasConcept C2776362946 @default.
• W2100024166 hasConcept C2779013556 @default.
• W2100024166 hasConcept C2779438470 @default.
• W2100024166 hasConcept C2780283643 @default.
• W2100024166 hasConcept C2780849966 @default.
• W2100024166 hasConcept C502942594 @default.
• W2100024166 hasConcept C71924100 @default.
• W2100024166 hasConceptScore W2100024166C121608353 @default.
• W2100024166 hasConceptScore W2100024166C125555471 @default.

• next